Our research group has a great experience in the development of chemometric methods for multivariate calibration, using different spectroscopic techniques, especially Near Infrared (NIR) spectrometry, Ion Mobility Spectrometry (IMS) and Raman, as much in discontinuous systems as in kinetic systems. The nature of the research is eminently applied, and it is focused on the improvement of the industrial production. The present and more important research line of the group is the development of new analytical methods to monitor industrial processes of interest: - New methodologies for the rapid analytical control of medicines - Monitoring the different steps of the pharmaceutical production process, from the raw material until the final product going by the intermediates - Establishing new methods for control of Esterification reactions of poliols with mixtures of acids for the obtaining of products of interest in pharmacy, cosmetic and foods. - Control of Microbiological fermentations - Control of the polymerization process for the obtaining of resins polyester In all studies the NIR spectroscopy has been analytical technique proposed. They are also studies on kinetic processes enzimatically catalyzed: - Enzymatic reactions used as models for two step reactions, or for reactions with an intermediate clearly defined, in aqueous medium - Catalytic effect of the lipases in esterification and hydrolysis reactions of carboxylic acids with chiral alcohols; in organic medium Besides all this, it continues the development of new NIR analytical methods for the analysis of mortars used in building, different applications in tannery, etc., as answer from demands of industries that contact with us. The complexity of the recorded signal requires the selection and the development of chemometric methods to extract the analytically relevant information. Usually in process control, we have 2on order signals, that have and intrinsically three-dimensional structure: sample concentration, signal and time. These methods are studied using conventional laboratory instrumentation, in easily controlled systems, before their application to industrial process control.
