The plasticizer butyl benzyl phthalate induces genomic changes in rat mammary gland after neonatal/prepubertal exposure.
Moral Cabrera, Raquel (Fox Chase Cancer Center (Filadèlfia, Estats Units d'Amèrica))
Wang, Richard (Fox Chase Cancer Center (Filadèlfia, Estats Units d'Amèrica))
Russo, Irma H. (Fox Chase Cancer Center (Filadèlfia, Estats Units d'Amèrica))
Mailo, Daniel A. (Fox Chase Cancer Center (Filadèlfia, Estats Units d'Amèrica))
Lamartiniere, Coral A. (University of Alabama at Birmingham. Department of Pharmacology and Toxicology (Birmingham, Regne Unit))
Russo, José (Fox Chase Cancer Center (Filadèlfia, Estats Units d'Amèrica))

Data: 2007
Resum: Background: Phthalate esters like n-butyl benzyl phthalate (BBP) are widely used plasticizers. BBP has shown endocrine-disrupting properties, thus having a potential effect on hormone-sensitive tissues. The aim of this study is to determine the effect of neonatal/prepubertal exposure (post-natal days 2–20) to BBP on maturation parameters and on the morphology, proliferative index and genomic signature of the rat mammary gland at different ages of development (21, 35, 50 and 100 days). Results: Here we show that exposure to BBP increased the uterine weight/body weight ratio at 21 days and decreased the body weight at time of vaginal opening. BBP did not induce significant changes on the morphology of the mammary gland, but increased proliferative index in terminal end buds at 35 days and in lobules 1 at several ages. Moreover, BBP had an effect on the genomic profile of the mammary gland mainly at the end of the exposure (21 days), becoming less prominent thereafter. By this age a significant number of genes related to proliferation and differentiation, communication and signal transduction were up-regulated in the glands of the exposed animals. Conclusion: These results suggest that BBP has an effect in the gene expression profile of the mammary gland.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; publishedVersion
Publicat a: BMC Genomics, Vol. 8, N. 453 (December 2007) , p. 1-12, ISSN 1471-2164

PMID: 18062813

12 p, 486.3 KB

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