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CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population
López Guimerà, Gemma (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Dashti, Hassan S. (Tufts University (Boston, Estats Units d'Amèrica). Nutrition and Genomics Laboratory)
Smith, Caren E. (Tufts University (Boston, Estats Units d'Amèrica). Nutrition and Genomics Laboratory)
Sánchez Carracedo, David (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Ordovas, José M. (Tufts University (Boston, Estats Units d'Amèrica). Nutrition and Genomics Laboratory)
Garaulet Aza, Marta (Universidad de Murcia. Departamento de Fisiología)

Date: 2014
Abstract: Objective: The goals of this research was (1) to analyze the role of emotional eating behavior on weight-loss progression during a 30-week weight-loss program in 1,272 individuals from a large Mediterranean population and (2) to test for interaction between CLOCK 3111 T/C SNP and emotional eating behavior on the effectiveness of the weight-loss program. Design and Methods: A total of 1,272 overweight and obese participants (BMI: 31±5 kg/m2), aged 20 to 65 years, attending outpatient weight-loss clinics were recruited for this analysis. Emotional eating behavior was assessed by the Emotional Eating Questionnaire (EEQ), a questionnaire validated for overweight and obese Spanish subjects. Anthropometric measures, dietary intake and weight-loss progression were assessed and analyzed throughout the 30-week program. Multivariate analysis and linear regression models were performed to test for gene-environment interaction. Results: Weight-loss progression during the 30-week program differed significantly according to the degree of emotional eating behavior. Participants classified as 'very emotional eaters' experienced more irregular (P = 0. 007) weight-loss, with a lower rate of weight decline (−0. 002 vs. −0. 003, P<0. 05) in comparison with less emotional eaters. The percentage of weight-loss was also significantly higher in 'non-emotional eaters' (P = 0. 009). Additionally, we identified a significant gene-environment interaction associated with weight-loss at the CLOCK 3111 T/C locus (P = 0. 017). By dichotomizing the emotional eating behavior score, linear regression analysis indicated that minor C allele carriers with a high emotional score (> = 11), lost significantly less weight than those C carriers with a low emotional score (<11) (P = 0. 005). Conclusions: Emotional eating behavior associates with weight-loss pattern, progression and total weight-loss. Additionally, CLOCK 3111 T/C SNP interacts with emotional eating behavior to modulate total weight loss. These results suggest that the assessment of this locus and emotional eating behavior could improve the development of effective, long-tern weight-management interventions.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Eating ; Eating habits ; Obesity ; Behavior ; Weight loss ; Emotions ; Body mass index ; Psychometrics
Published in: PloS one, Vol. 9, Issue 6 (June 2014) , p.e99152, ISSN 1932-6203

DOI: 10.1371/journal.pone.0099152
PMID: 24905098

8 p, 577.2 KB

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Articles > Research articles
Articles > Published articles

 Record created 2015-10-08, last modified 2020-08-16

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