CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population
López-Guimerà, Gemma (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Dashti, Hassan S. (Tufts University (Boston, Estats Units d'Amèrica). Nutrition and Genomics Laboratory)
Smith, Caren E. (Tufts University (Boston, Estats Units d'Amèrica). Nutrition and Genomics Laboratory)
Sánchez-Carracedo, David (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Ordovas, José M. (Tufts University (Boston, Estats Units d'Amèrica). Nutrition and Genomics Laboratory)
Garaulet Aza, Marta (Universidad de Murcia. Departamento de Fisiología)

Date:	2014
Abstract:	Objective: The goals of this research was (1) to analyze the role of emotional eating behavior on weight-loss progression during a 30-week weight-loss program in 1,272 individuals from a large Mediterranean population and (2) to test for interaction between CLOCK 3111 T/C SNP and emotional eating behavior on the effectiveness of the weight-loss program. Design and Methods: A total of 1,272 overweight and obese participants (BMI: 31±5 kg/m2), aged 20 to 65 years, attending outpatient weight-loss clinics were recruited for this analysis. Emotional eating behavior was assessed by the Emotional Eating Questionnaire (EEQ), a questionnaire validated for overweight and obese Spanish subjects. Anthropometric measures, dietary intake and weight-loss progression were assessed and analyzed throughout the 30-week program. Multivariate analysis and linear regression models were performed to test for gene-environment interaction. Results: Weight-loss progression during the 30-week program differed significantly according to the degree of emotional eating behavior. Participants classified as 'very emotional eaters' experienced more irregular (P = 0. 007) weight-loss, with a lower rate of weight decline (-0. 002 vs. -0. 003, P<0. 05) in comparison with less emotional eaters. The percentage of weight-loss was also significantly higher in 'non-emotional eaters' (P = 0. 009). Additionally, we identified a significant gene-environment interaction associated with weight-loss at the CLOCK 3111 T/C locus (P = 0. 017). By dichotomizing the emotional eating behavior score, linear regression analysis indicated that minor C allele carriers with a high emotional score (.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Eating ; Eating habits ; Obesity ; Behavior ; Weight loss ; Emotions ; Body mass index ; Psychometrics
Published in:	PloS one, Vol. 9, Issue 6 (June 2014) , p.e99152, ISSN 1932-6203

DOI: 10.1371/journal.pone.0099152
PMID: 24905098

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