Risc d'hepatotoxicitat aguda greu associada a l'ús de medicaments
Sabaté Gallego, Mònica
Ibáñez Mora, Luisa, dir.
Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia

Imprint: [Barcelona] : Universitat Autònoma de Barcelona, 2015
Description: 1 recurs electrònic (128 p.)
Note: Tesi doctoral - Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia, 2015 25). Amoxicillin, metoclopramide, captopril and enalapril, furosemide, hydrochlorothiazide, fluoxetine, paroxetine, diazepam, alprazolam, lorazepam, metamizole, low-dose acetylsalicylic acid and salbutamol showed the lowest risk (point RR 5). In four cases the role of paracetamol was judged to be unrelated, in two unlikely, and these were excluded from evaluation. In seven of the remaining 26 cases, the RUCAM score associated with paracetamol was higher than that associated with other concomitant medications. The estimated incidence of ALI related to the use of paracetamol in therapeutic dosages was 0.4 per million inhabitants older than 15 years of age and per year (99%CI, 0.2-0.8) and of 10 per million paracetamol users-year (95% CI 4.3-19.4). Conclusions: This study provides a risk estimation of serious liver disease for various drugs that will be useful in its diagnosis and management, and when comparing with the drug therapeutic benefit in each indication. Some observed associations would be worth testing in specific studies. Regarding the use of paracetamol our results indicate that paracetamol in therapeutic dosages may be considered in the causality assessment in non-alcoholic patients with liver injury, even if the estimated incidence of ALI related to paracetamol appears to be low.
Rights: L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons Creative Commons
Language: Català.
Document: Tesis i dissertacions electròniques ; doctoralThesis ; publishedVersion
Subject: Farmacoepidemiologia ; Farmacoepidemiología ; Pharmacoepidemiology ; Farmacovigilancia ; Pharmacovigilance ; Hepatotoxicitat ; Hepatotoxicity
ISBN: 9788449054525

Adreça alternativa: https://hdl.handle.net/10803/313239

128 p, 1.5 MB

The record appears in these collections:
Research literature > Doctoral theses

 Record created 2015-10-19, last modified 2019-02-02

   Favorit i Compartir