Voltammetric sensor for theophylline using sol-gel immobilized molecularly imprinted polymer particles
Bates, Ferdia (Universitat Autònoma de Barcelona. Departament de Química)
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química)

Fecha:	2015
Resumen:	Application of Molecularly Imprinted Polymers (MIPs) to sensor substrates holds great promise within the field of electrochemical sensing due to their low price, tailored selectivity and facile synthesis protocols. Though MIPs can be synthesised directly onto the surface of sensors via layer or film deposition, this can be difficult due to the high number of interdependent steps involved in their synthesis. For this reason, synthesis of MIP particles is more frequently employed by synthetic and non-specialist laboratories alike. There is, however a lack of immobilisation protocols for these particles. Herein, there is presented a sol-gel based immobilisation method for MIP particles for the development of an electrochemical sensor. The macroporous precipitation-polymerised particles were imprinted with Theophylline, combined with graphite in the sol-gel and deposited on an electrode surface. The sensor was tested using differential pulse voltammetry. A limit of detection of 1µM and a relative standard deviation of 6. 85% was observed for the primary analyte. The electrode was regenerated via a thermal washing process with a signal loss of 29. 3% following the initial regeneration and 2. 35% per subsequent regeneration.
Ayudas:	European Commission 264772 Ministerio de Ciencia e Innovación CTQ2010-17099
Nota:	El títol del pre-print va ser: Development of a voltammetric sensor for theophylline with sol-gel immobilised molecularly imprinted polymer particles
Derechos:	Tots els drets reservats.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió sotmesa a revisió
Materia:	Molecularly imprinted polymers (MIP) ; Sol-gel ; Graphite ; Theophylline ; Voltammetry
Publicado en:	Mikrochimica acta, Vol. 182, Issue 5-6 (April 2015) , p. 933-942, ISSN 1436-5073

DOI: 10.1007/s00604-014-1413-4

Pre-print 21 p, 1.5 MB

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