Cetacean Morbillivirus: Current Knowledge and Future Directions
Van Bressem, Marie-Françoise (Peruvian Centre for Cetacean Research (Lima, Perú))
Duignan, Pádraig J. (University of Calgary)
Banyard, Ashley (Animal and Plant Health Agency)
Barbieri, Michelle (The Marine Mammal Centre (Sausalito, Estats Units d'Amèrica))
Colegrove, Kathleen M. (University of Illinois at Maywood)
De Guise, Sylvain (University of Connecticut. Department of Pathobiology and Veterinary Science)
Dobson, Andrew (Princeton University. Department of Ecology and Evolutionary Biology)
Domingo, Mariano (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Fauquier, Deborah (National Marine Fisheries Service (Silver spring, USA))
Fernandez, Antonio (Universidad de Las Palmas de Gran Canaria. Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de los Alimentos)
Goldstein, Tracey (University of California. School of Veterinary Medicine)
Grenfell, Bryan (Princeton University. Department of Ecology and Evolutionary Biology)
Groch, Kátia R. (Universidade de São Paulo. Department of Pathology)
Gulland, Frances (The Marine Mammal Centre (Sausalito, Estats Units d'Amèrica))
Jensen, Brenda A. (Hawaii Pacific University)
Jepson, Paul D. (Institute of Zoology (Londres, Regne Unit))
Hall, Ailsa (University of St. Andrews. Scottish Oceans Institute)
Kuiken, Hall (Erasmus MC. Department of Viroscience (Rotterdam, Paisos Baixos))
Mazzariol, Sandro (Università di Padua)
Morris, Sinead E. (Princeton University. Department of Ecology and Evolutionary Biology)
Nielsen, Ole (Department of Fisheries and Oceans Canada, Central and Arctic Region)
Raga, Juan Antonio (Universitat de València)
Rowles, Teresa K. (National Marine Fisheries Service (Silver Spring, Estats Units d'Amèrica))
Saliki, Jeremy (University of Georgia)
Sierra, Eva (Universidad de Las Palmas de Gran Canaria)
Stephens, Nahiid (Murdoch University (Perth, Austràlia))
Stone, Brett (QML Vetnostics (Queensland, Austràlia))
Tomo, Ikuko (South Australian Museum (Adelaide, Austràlia))
Wang, Jianning (Commonwealth Scientific and Industrial Research Organisation (Victoria, Austràlia))
Waltzek, Thomas (University of Florida)
Wellehan, James F. X. (University of Florida)

Data:	2014
Resum:	We review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV) and the diagnosis and pathogenesis of sociated disease, with six different strains detected in cetaceans worldwide. CeMV has caused epidemics with high mortality in odontocetes in Europe, the USA and Australia. It represents a distinct species within the Morbillivirus genus. Although most CeMV strains are phylogenetically closely related, recent data indicate that morbilliviruses recovered from Indo-Pacific bottlenose dolphins (Tursiops aduncus), from Western Australia, and a Guiana dolphin (Sotalia guianensis), from Brazil, are divergent. The signaling lymphocyte activation molecule (SLAM) cell receptor for CeMV has been characterized in cetaceans. It shares higher amino acid identity with the ruminant SLAM than with the receptors of carnivores or humans, reflecting the evolutionary history of these mammalian taxa. In Delphinidae, three amino acid substitutions may result in a higher affinity for the virus. Infection is diagnosed by histology, immunohistochemistry, virus isolation, RT-PCR, and serology. Classical CeMV-associated lesions include bronchointerstitial pneumonia, encephalitis, syncytia, and lymphoid depletion associated with immunosuppression. Cetaceans that survive the acute disease may develop fatal secondary infections and chronic encephalitis. Endemically infected, gregarious odontocetes probably serve as reservoirs and vectors. Transmission likely occurs through the inhalation of aerosolized virus but mother to fetus transmission was also reported.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cetacean morbillivirus ; Epidemics ; Mass stranding ; SLAM ; Phylogeny ; Pathogenesis ; Diagnosis ; Endemic infections
Publicat a:	Viruses, Vol. 6, no. 12 (2014) , p. 5145-5181, ISSN 1999-4915

DOI: 10.3390/v6125145
PMID: 25533660

37 p, 1.6 MB

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