Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system
Wesoly, Malgorzata (Warsaw University of Technology. Department of Microbioanalytics)
Cetó Alsedà, Xavier (Universitat Autònoma de Barcelona. Departament de Química)
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química)
Ciosek, Patrycja (Warsaw University of Technology. Department of Microbioanalytics)
Wróblewski, Wojciech (Warsaw University of Technology. Department of Microbioanalytics)

Date:	2016
Abstract:	An advanced potentiometric electronic tongue and Sequential Injection Analysis (SIA) measurement system was applied for the quantitative analysis of mixtures containing three active pharmaceutical ingredients (APIs): acetaminophen, ascorbic acid and acetylsalicylic acid, in the presence of various amounts of caffeine as interferent. The flow-through sensor array was composed of miniaturized classical ion-selective electrodes based on plasticized PVC membranes containing only ion exchangers. Partial Least Squares (PLS) analysis of the steady-state sensor array responses, measured in API mixtures prepared by the SIA system permitted a correct quantitative analysis of acetylsalicylic acid and ascorbic acid. Further optimization using multiway PLS fed by dynamic responses without additional feature extraction did not improve significantly the resolution of acetaminophen. Lastly, the chemometric treatment, involving the extraction of dynamic components of the transient response employing the Wavelet transform, the removal of less-significant coefficients by means of Causal Index pruning and training of an Artificial Neural Network (ANN) with the selected coefficients, allowed the simultaneous determination of all the three studied APIs, while counterbalancing any interference due to caffeine.
Note:	Research funding: National Science Centre. Grant Numbers: DEC-2013/09/B/ST4/00957, LIDER/17/202/L-1/09/NCBiR/2010
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió sotmesa a revisió
Subject:	Pharmaceutical analysis ; Active pharmaceutical ingredients (APIs) ; Ion-selective electrodes ; Automated electronic tongue ; Sequential injection analysis
Published in:	Electroanalysis, Vol. 28, Issue 3 (March 2016) , p. 626-632, ISSN 1521-4109

DOI: 10.1002/elan.201500407

Pre-print 20 p, 1.2 MB

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