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Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction.
Dierssen, Mara (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Gratacòs, Mònica (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Sahún, Ignasi (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Martín, Miguel (Universitat Pompeu Fabra. Àrea de Neurofarmacologia)
Gallego, Xavier (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Amador-Arjona, Alehandro (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Martínez de Lagrán María (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Murtra, Patricia (Universitat Pompeu Fabra. Àrea de Neurofarmacologia)
Martí, Eulalia (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Pujana, Miguel A. (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Ferrer, Isidre (Hospital Prínceps d’Espanya. Àrea de neuropatologia)
Dalfo Capella, Esther (Universitat Autònoma de Barcelona. Departament de Biologia i Bioquímica Molecular)
Martínez-Cué, Carmen (Universidad de Cantabria. Departamento de Psicologia y Farmacologia)
Flórez, Jesús (Universidad de Cantabria. Departamento de Psicologia y Farmacologia)
Torres-Peraza, Jesús F. (Universitat de Barcelona. Departament de Biologia Cel·lular i Anatomia Patològica)
Alberch i Vié, Jordi (Universitat de Barcelona. Departament de Biologia Cel·lular i Anatomia Patològica)
Maldonado, Rafael (Universitat Pompeu Fabra. Àrea de Neurofarmacologia)
Fillat, Cristina (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Estivill, Xavier (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)

Date: 2006
Abstract: Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. TgNTRK3 mice show increased anxiety-like behavior and enhancement of panic reaction in the mouse defense test battery, along with an increase in the number and density of catecholaminergic (tyrosine hydroxylase positive) neurons in locus coeruleus and substantia nigra. Furthermore, treatment of TgNTRK3 mice with diazepam significantly attenuated the anxiety-like behaviors in the plus maze. These results provide evidence for the involvement of TrkC in the development of noradrenergic neurons in the central nervous system with consequences on anxiety-like behavior and panic reaction. Thus, changes in TrkC expression levels could contribute to the phenotypic expression of panic disorder through a trophic effect on noradrenergic neurons in the locus coeruleus. Our results demonstrate that the elevated NT3-TrkC tone via overexpression of TrkC in the brain may constitute a molecular mechanism for the expression of anxiety and anxiety.
Rights: Tots els drets reservats.
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Panic disorder ; NT-3 ; TrkC ; Anxiety-like behavior ; Mouse defense test battery ; Locus coeruleus
Published in: Neurobiology of disease, Vol. 24, Num. 2 (2006) , p. 403-18, ISSN 0969-9961

DOI: 10.1016/j.nbd.2006.07.015


16 p, 1020.6 KB

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Articles > Published articles

 Record created 2016-11-07, last modified 2019-03-25



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