Web of Science: 2 citations, Scopus: 4 citations, Google Scholar: citations,
Evaluation of various biomarkers for kidney monitoring during canine leishmaniosis treatment
Pardo-Marín, Luis (Universidad de Murcia. Facultad de Veterinaria)
Martínez-Subiela, Silvia (Universidad de Murcia. Facultad de Veterinaria)
Pastor Milán, Josep (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animal)
Tvarijonaviciute, Asta (Universidad de Murcia. Facultad de Veterinaria)
Garcia-Martinez, Juan Diego (Universidad de Murcia. Facultad de Veterinaria)
Segarra López, Sergi (R&D Bioiberica S.A.)
Cerón Madrigal, José Joaquín (Universidad de Murcia. Facultad de Veterinaria)

Date: 2017
Abstract: Background: The objective of this study was to evaluate and compare the evolution of the profile currently recommended by the International Renal Interest Society (IRIS) (sCr, UPC and sSDMA) with a panel of other different kidney biomarkers during treatment for canine leishmaniosis. This panel included three urinary glomerular biomarkers (uIgG, uCRP and uferritin) and three urinary tubular biomarkers (uGGT, uNAG and uRBP). These biomarkers were measured in two groups of dogs with canine leishmaniosis at IRIS stage I. Group 1: dogs showing proteinuria (UPC > 0. 5) before treatment which did not decrease after treatment; Group 2: dogs showing proteinuria before treatment which decreased after treatment. Results: Group 1 showed no significant changes in any biomarker after treatment. In group 2, among the biomarkers recommended by the IRIS, only UPC showed a significant decrease after treatment. However all biomarkers of glomerular damage showed a significant decrease after treatment, with uIgG/Cr and uCRP/Cr showing the greater decreases. In addition uRBP/Cr and uNAG/Cr showed significant decreases after treatment. Conclusions: In dogs with leishmaniosis at IRIS stage I that reduced UPC after treatment, there were no significant changes in serum creatinine and sSDMA. However, all the urine biomarkers evaluated with exception of uGGT showed a significant decrease. These decreases were more evident in those markers related with glomerular function, being uIgG/Cr the biomarker more associated with UPC. Further studies involving a larger number of animals and histological analysis of the kidney would be recommended to confirm these findings and evaluate the routine practical use of these urine biomarkers in canine leishmaniosis.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Urine ; Kidney ; Immunoglobulin G (IgG) ; UPC ; Creatinine ; Symmetric dimethylarginine (SDMA) ; Gamma glutamyl-transpeptidase (GGT) ; Retinol-binding protein (RBP)
Published in: BMC Veterinary research, Vol. 13, Núm. 31 (January 2017) , p. 1-7, ISSN 1746-6148

DOI: 10.1186/s12917-017-0956-0
PMID: 28114941


7 p, 381.1 KB

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Articles > Research articles
Articles > Published articles

 Record created 2017-03-08, last modified 2019-10-04



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