Web of Science: 4 citas, Scopus: 2 citas, Google Scholar: citas,
Impact of Obstructive Sleep Apnea on the Levels of Placental Growth Factor (PlGF) and Their Value for Predicting Short-Term Adverse Outcomes in Patients with Acute Coronary Syndrome
Barcelo, Antonia (Hospital Universitari Son Espases (Illes Balears))
Bauça, Josep Miquel (Hospital Universitari Son Espases (Illes Balears))
Yañez, Ayna (Hospital Universitari Son Espases (Illes Balears))
Abad, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Spanish Sleep Group

Fecha: 2016
Resumen: BACKGROUND: Placental growth factor (PlGF) induces angiogenesis and promotes tissue repair, and plasma PlGF levels change markedly during acute myocardial infarction (AMI). Currently, the impact of obstructive sleep apnea (OSA) in patients with AMI is a subject of debate. Our objective was to evaluate the relationships between PlGF levels and both the severity of acute coronary syndrome (ACS) and short-term outcomes after ACS in patients with and without OSA. METHODS: A total of 538 consecutive patients (312 OSA patients and 226 controls) admitted for ACS were included in this study. All patients underwent polygraphy in the first 72 hours after hospital admission. The severity of disease and short-term prognoses were evaluated during the hospitalization period. Plasma PlGF levels were measured using an electrochemiluminescence immunoassay. RESULTS: Patients with OSA were significantly older and more frequently hypertensive and had higher BMIs than those without OSA. After adjusting for age, smoking status, BMI and hypertension, PlGF levels were significantly elevated in patients with OSA compared with patients without OSA (19. 9 pg/mL, interquartile range: 16. 6-24. 5 pg/mL; 18. 5 pg/mL, interquartile range: 14. 7-22. 7 pg/mL; p<0. 001), and a higher apnea-hypopnea index (AHI) was associated with higher PlGF concentrations (p<0. 003). Patients with higher levels of PlGF had also an increased odds ratio for the presence of 3 or more diseased vessels and for a Killip score>1, even after adjustment. CONCLUSIONS: The results of this study show that in patients with ACS, elevated plasma levels of PlGF are associated with the presence of OSA and with adverse outcomes during short-term follow-up. TRIAL REGISTRATION: ClinicalTrials. gov NCT01335087.
Nota: Número d'acord de subvenció ISCIII/FIS/PI10/02763
Nota: Número d'acord de subvenció ISCIII/FIS/PI10/02745
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Publicado en: PloS one, Vol. 11 Núm. 3 (March 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0147686
PMID: 26930634

12 p, 237.9 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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 Registro creado el 2017-05-22, última modificación el 2018-10-21

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