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Página principal > Artículos > Artículos publicados > The HCPro from the Potyviridae family : |
Fecha: | 2018 |
Resumen: | RNA viruses have very compact genomes and so provide a unique opportunity to study how evolution works to optimize the use of very limited genomic information. A widespread viral strategy to solve this issue concerning the coding space relies on the expression of proteins with multiple functions. Members of the family Potyviridae, the most abundant group of RNA viruses in plants, offer several attractive examples of viral factors which play roles in diverse infection-related pathways. The Helper Component Proteinase (HCPro) is an essential and well-characterized multitasking protein for which at least three independent functions have been described: (i) viral plant-to-plant transmission; (ii) polyprotein maturation; and (iii) RNA silencing suppression. Moreover, multitudes of host factors have been found to interact with HCPro. Intriguingly, most of these partners have not been ascribed to any of the HCPro roles during the infectious cycle, supporting the idea that this protein might play even more roles than those already established. In this comprehensive review, we attempt to summarize our current knowledge about HCPro and its already attributed and putative novel roles, and to discuss the similarities and differences regarding this factor in members of this important viral family. |
Ayudas: | Ministerio de Ciencia e Innovación BIO2016-80572-R Ministerio de Ciencia e Innovación AGL2016-75529-R Ministerio de Ciencia e Innovación BIO2015-73900-JIN Ministerio de Economía y Competitividad SEV-2015-0533 Ministerio de Economía y Competitividad PlantKBBEPCIN-2013-056 Ministerio de Ciencia e Innovación BIO2013-49053-R Ministerio de Ciencia e Innovación AGL2013-42537-R Ministerio de Economía y Competitividad SEV-2013-0347 |
Derechos: | Tots els drets reservats. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió acceptada per publicar |
Materia: | Multifunctional proteins ; Proteinase ; RNA silencing ; Suppressor ; Transmission |
Publicado en: | Molecular plant pathology, Vol. 19, issue3 (March 2018) , p. 744-763, ISSN 1364-3703 |
Post-print 54 p, 2.0 MB |