Integrative meta-analysis of protein interaction data identified multiple GID/MRCTLH protein complexes in plants
Miquel, Mercè (Centre de Recerca en Agrigenòmica)
Vicient Sánchez, Carlos M. (Centre de Recerca en Agrigenòmica)

Date:	2017
Abstract:	GID/MRCTLH is a protein complex involved in the regulation of several cellular processes through the polyubiquitination and proteosome degradation. It has been described in yeast and mammals. Genes coding for homologous proteins are also present in plant genomes but have been little studied. BLAST analyses revealed that genes coding for members of the GID/MRCTLH complex are found in multiple copies in plants, compared to mammals and yeast. The potential structure of the Arabidopsis GID/MRCTLH complex was estimated based on the Arabidopsis protein interaction database Interactome 2. 0. According to these data, Arabidopsis may contain two GID/MRCTLH complexes instead of the one described in yeast and mammals. The structure of the two Arabidopsis complexes seem to be similar to the yeast GID complex, and seem to interact with several other proteins out of the complex. These data suggest that, similarly to yeast and mammals, the plant GID/MRCTLH complexes are involved in the regulation of several cellular processes through proteosome protein degradation.
Grants:	Ministerio de Ciencia e Innovación BIO2001-1721 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1434
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	GID ; MRCTLH ; Protein interaction ; Ubiquitination ; Arabidopsis
Published in:	Plant Omics, Vol. 10, issue 4 (Jul. 2017) , p. 169-175, ISSN 1836-0661

DOI: 10.21475/poj.10.04.17.pne212

7 p, 719.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > CRAG (Centre for Research in Agricultural Genomics)
Articles > Research articles
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