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Pàgina inicial > Articles > Articles publicats > Biodegradable FeMnSi sputter-coated macroporous polypropylene membranes for the sustained release of drugs |
Data: | 2017 |
Resum: | Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms. |
Ajuts: | Ministerio de Economía y Competitividad IJCI-2015-27030 Ministerio de Economía y Competitividad MAT2014-57960-C3-1-R Ministerio de Economía y Competitividad MAT2014-57960-C3-3-R Ministerio de Economía y Competitividad RYC-2012-10839 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-1015 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-524 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Biodegradable material ; Porous membrane ; Drug delivery ; Hybrid material |
Publicat a: | Nanomaterials, Vol. 7 (2017) , p. 155, ISSN 2079-4991 |
12 p, 2.7 MB |