Cardioembolic Stroke Diagnosis Using Blood Biomarkers
Llombart, VÍctor (Hospital Universitari Vall d'Hebron)
García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fernandez-Cadenas, Israel (Fundació per la Docència i Recerca Mútua de Terrassa)
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Date:	2013
Abstract:	Stroke is one of the main causes of death and disability in the world. Cardioembolic etiology accounts for approximately one fifth of all ischemic strokes whereas 25-30% remains undetermined even after an advanced diagnostic workup. Despite there is not any biomarker currently approved to distinguish cardioembolic stroke among other etiologies in clinical practice the use of biomarkers represents a promising valuable complement to determine stroke etiology reducing the number of cryptogenic strokes and aiding in the prescription of the most appropriated primary and secondary treatments in order to minimize therapeutic risks and to avoid recurrences. In this review we present an update about specific cardioembolic stroke-related biomarkers at a protein, transcriptomic and genetic level. Finally, we also focused on reported biomarkers associated with atrial fibrillation (a cardiac illness strongly related with cardioembolic stroke subtype) thus with a potential to become biomarkers to detect cardioembolic stroke in the future.
Grants:	Instituto de Salud Carlos III FI09-00017
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Atrial ; Biomarker ; Cardioembolic ; Classification ; Etiology ; Fibrillation ; Stroke ; MiRNA
Published in:	Current Cardiology Reviews, Vol. 9 (november 2013) , p. 340-352, ISSN 1875-6557

DOI: 10.2174/1573403X10666140214122633
PMID: 24527683

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