Digestive Symptoms in Healthy People and Subjects With Irritable Bowel Syndrome
Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)
Guyonnet, Denis (Danone Research)
Donazzolo, Yves (Eurofins Optimed)
Gendre, David (Biorfortis)
Tanguy, Jérôme (Danone Research)
Guarner, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina)

Fecha:	2015
Resumen:	The aim of this study was to validate the ability of symptom frequency questionnaire to differentiate between irritable bowel syndrome (IBS) patients and healthy subjects. A digestive symptom frequency questionnaire (DSFQ) was previously used in a food efficacy trial in a non-IBS population with mild gastrointestinal symptoms. We compared 2 well-defined populations: 100 IBS patients fulfilling Rome III criteria (mean age 32 y; range, 18 to 59 y), and 100 sex-matched and age-matched healthy subjects. Frequency of individual digestive symptoms (abdominal pain/discomfort, bloating, flatulence, borborygmi) was assessed using a 5-point Likert scale (from none to everyday of the week) and the IBS severity with the IBS-SSS questionnaire. Health-Related Quality of life (HRQoL) was assessed with the Food and Benefits Assessment (FBA) and Functional Digestive Disorders Quality of Life (FDDQL) questionnaires. The digestive (dis)comfort dimension of these questionnaires was considered as the main dimension for HRQoL. The DSFQ discriminated IBS from healthy subjects with a significant difference (P <0. 001) between groups (estimated mean difference=5. 58; 95% CI, 4. 91-6. 28). On the basis of the ROC curve (AUC=0. 9479), a cutoff value of 5 gives a sensitivity of 92% and a specificity of 84%, with a positive likelihood ratio of 5. 75. Composite score of symptoms correlated strongly (P <0. 0001) with digestive discomfort measured by FDDQL (−0. 816), digestive comfort measured by FBA (−0. 789), and the IBS-SSS score (0. 762). Measurement of digestive symptom frequency by means of the DSFQ can differentiate IBS from healthy subjects, and shows a good correlation with other validated questionnaires (clinical trial #NCT01457378).
Nota:	Altres ajuts: Supported in full by Danone Research
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès, altres
Documento:	Article ; recerca ; Versió publicada
Materia:	Digestive symptoms ; Patient-reported outcome ; Irritable bowel syndrome ; Quality of life
Publicado en:	Journal of Clinical Gastroenterology, Vol. 49 (july 2015) , p. e64-e70, ISSN 1539-2031

DOI: 10.1097/MCG.0000000000000178
PMID: 25014236

7 p, 257.9 KB

El registro aparece en las colecciones:
Artículos > Artículos de investigación
Artículos > Artículos publicados