Random-start GnRH antagonist for emergency fertility preservation : a self-controlled trial
Checa, Miguel Angel (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Brassesco, Mario (Centro de Infertilidad y Reproducción Humana)
Sastre, Margalida (Parc de Salut Mar. Departament d'Obstetrícia i Ginecologia)
Gómez, Manuel (Centro de Infertilidad y Reproducción Humana)
Herrero García, Julio 1968- (Centro de Reproducción Asistida Sagrada Familia, Clínica Sagrada Familia)
Marque, Laura (Centro de Reproducción Asistida Sagrada Familia, Clínica Sagrada Familia)
Brassesco, Arturo (Centro de Infertilidad y Reproducción Humana)
Espinós, Juan José (Centro de Reproducción Asistida Sagrada Familia, Clínica Sagrada Familia)

Data:	2015
Resum:	The aim of this study is to evaluate the feasibility and safety of random-start controlled ovarian hyperstimulation (COH) for emergency fertility preservation, regardless of the phase of the menstrual cycle. A self-controlled pilot clinical trial (NCT01385332) was performed in an acute-care teaching hospital and in two private reproductive centers in Barcelona, Spain. Eleven egg donors participated in the study. Two random-start gonadotropin-releasing hormone (GnRH) antagonist protocols were assessed in which ganirelix was initiated on either day 10 (protocol B) or on day 20 (protocol C) of the menstrual cycle and was continued until estradiol levels were below 60 pg/dL. These protocols were compared with a standard protocol (protocol A). The main outcome of interest was the number of metaphase 2 oocytes retrieved. Results from this study show that the number of mature oocytes retrieved was comparable across the different protocols (14. 3±4. 6 in the standard protocol versus 13. 0±9. 1 and 13. 2±5. 2 in protocols B and C, respectively; values expressed as mean ± standard deviation). The mean number of days needed for a GnRH antagonist to lower estradiol levels, as well as the ongoing pregnancy rates, were also similar when protocols B (stimulation in follicular phase) and C (stimulation on luteal phase) were compared with protocol A (standard stimulation). GnRH antagonists can be effectively used for random-start controlled ovarian hyperstimulation with an ovarian response similar to that of standard protocols, and the antagonists appear suitable for emergency fertility preservation in cancer patients.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Controlled ovarian hyperstimulation ; GnRH antagonists ; Emergency fertility preservation ; Cancer patients
Publicat a:	International Journal of Women's Health, Vol. 7 (february 2015) , p. 219-225, ISSN 1179-1411

DOI: 10.2147/IJWH.S66743
PMID: 25709506

7 p, 662.6 KB

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