Pulmonary hemodynamic profile in chronic obstructive pulmonary disease
Portillo, Karina ![ORCID Identifier](/img/uab/orcid.ico)
(Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Torralba, Yolanda (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Blanco, Isabel ![ORCID Identifier](/img/uab/orcid.ico)
(Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Burgos, Felip (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Rodríguez-Roisin, Robert (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Rios, Jose (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Roca, Josep
(Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Barberà i Mir, Joan Albert
(Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Date: |
2015 |
Abstract: |
Few data are available in regards to the prevalence of pulmonary hypertension (PH) in the broad spectrum of COPD. This study was aimed at assessing the prevalence of PH in a cohort of COPD patients across the severity of airflow limitation, and reporting the hemodynamic characteristics at rest and during exercise. We performed a retrospective analysis on COPD patients who underwent right-heart catheterization in our center with measurements obtained at rest (n=139) and during exercise (n=85). PH was defined as mean pulmonary artery pressure (mPAP) ≥25 mmHg and pulmonary capillary wedge pressure <15 mmHg. Exercise-induced PH (EIPH) was defined by a ratio of ΔmPAP/Δcardiac output >3. PH was present in 25 patients (18%). According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification, PH prevalence in GOLD 2 was 7% (3 patients); 25% (14 patients) in GOLD 3; and 22% (8 patients) in GOLD 4. Severe PH (mPAP ≥35 mmHg) was identified in four patients (2. 8%). Arterial partial oxygen pressure was the outcome most strongly associated with PH (r =−0. 29, P <0. 001). EIPH was observed in 60 patients (71%) and had a similar prevalence in both GOLD 2 and 3, and was present in all GOLD 4 patients. Patients with PH had lower cardiac index during exercise than patients without PH (5. 0±1. 2 versus 6. 7±1. 4 L/min/m 2, respectively; P =0. 001). PH has a similar prevalence in COPD patients with severe and very-severe airflow limitation, being associated with the presence of arterial hypoxemia. In contrast, EIPH is highly prevalent, even in moderate COPD, and might contribute to limiting exercise tolerance. |
Grants: |
Instituto de Salud Carlos III EC07-90049
|
Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by-nc.ico) |
Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Subject: |
Pulmonary hypertension ;
Right heart catheterization ;
Cardiac index ;
GOLD |
Published in: |
International journal of COPD, Vol. 10 (july 2015) , p. 1313-1320, ISSN 1178-2005 |
DOI: 10.2147/COPD.S78180
PMID: 26203238
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Record created 2018-01-31, last modified 2023-09-06