Web of Science: 4 citas, Scopus: 4 citas, Google Scholar: citas
Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure
Ballester, Maria Rosa (Institut d'Investigació Biomèdica Sant Pau)
Roig, Eulàlia (Institut d'Investigació Biomèdica Sant Pau)
Gich, Ignasi (Institut d'Investigació Biomèdica Sant Pau)
Puntes, Montse (Institut d'Investigació Biomèdica Sant Pau)
Delgadillo, Joaquín (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Santos, Benjamín (Ferrer Internacional, S.A.)
Antonijoan Arbós, Rosa Ma. (Rosa María) (Institut d'Investigació Biomèdica Sant Pau)

Fecha: 2015
Resumen: Diuretics are the primary treatment for the management of chronic heart failure (HF) symptoms and for the improvement of acute HF symptoms. The rate of delivery to the site of action has been suggested to affect diuretic pharmacodynamics. The main objective of this clinical trial was to explore whether a prolonged release tablet formulation of torasemide (torasemide-PR) was more natriuretically efficient in patients with chronic HF compared to immediate-release furosemide (furosemide-IR) after a single-dose administration. Moreover, the pharmacokinetics of torasemide-PR, furosemide-IR, and torasemide-IR were assessed in chronic HF patients as well as urine pharmacodynamics. Randomized, open-label, blinded-endpoint, crossover, and single-dose Phase I clinical trial with three experimental periods. Torasemide-PR and furosemide-IR were administered as a single dose in a crossover fashion for the first two periods, and torasemide-IR 10 mg was administered for the third period. Blood and urine samples were collected at fixed timepoints. The primary endpoint was the natriuretic efficiency after administration of torasemide-PR and furosemide-IR, defined as the ratio between the average drug-induced natriuresis and the average drug recovered in urine over 24 hours. Ten patients were included and nine completed the study. Here, we present the results from nine patients. Torasemide-PR was more natriuretically efficient than furosemide-IR (0. 096±0. 03 mmol/μg vs 0. 015±0. 0007 mmol/μg; P <0. 0001). Mictional urgency was lower and more delayed with torasemide-PR than with furosemide-IR. In a study with a limited sample size, our results suggest that 10 mg of torasemide-PR is more natriuretically efficient than 40 mg of furosemide-IR after single-dose administration in patients with chronic HF over a 24-hour collection period. Further studies are necessary to evaluate potential pharmacodynamic differences between torasemide formulations and to assess its impact on clinical therapeutics.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Torasemide ; Furosemide ; Controlled-release preparation ; Efficiency ; Heart failure ; Pharmacodynamics
Publicado en: Drug Design, Development and Therapy, Vol. 9 (august 2015) , p. 4291-4302, ISSN 1177-8881

PMID: 26273191
DOI: 10.2147/DDDT.S86300


12 p, 646.0 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació Biomèdica Sant Pau
Artículos > Artículos de investigación
Artículos > Artículos publicados

 Registro creado el 2018-01-31, última modificación el 2019-07-23



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