Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence : Report of Two Cases
Roncero, Carlos (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Palma-Álvarez, Raúl Felipe (Hospital Universitari Vall d'Hebron)
Ros-Cucurull, Elena (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Barral, Carmen (Hospital Universitari Vall d'Hebron)
Gonzalvo, Begoña (Hospital Universitari Vall d'Hebron)
Corominas-Roso, Margarida (Hospital Universitari Vall d'Hebron)
Casas Brugué, Miquel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Grau-López, Lara (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Date:	2016
Abstract:	Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further.
Grants:	Instituto de Salud Carlos III FISPI13-1911
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Estudi clínic ; recerca ; Article ; Versió publicada
Subject:	Cocaine-induced psychosis ; Cocaine dependence ; Brain-derived neurotrophic factor ; Biological marker ; Psychosis
Published in:	Clinical Psychopharmacology and Neuroscience, Vol. 14 (february 2016) , p. 109-113, ISSN 2093-4327

DOI: 10.9758/cpn.2016.14.1.109
PMID: 26792050

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