Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder
Demirtaş, Murat (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions)
Tornador, Cristian (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions)
Falcón, Carles (Fundació Pasqual Maragall)
López-Solà, Marina (Parc de Salut Mar)
Hernández-Ribas, Rosa (Centro de Investigación Biomédica en Red de Salud Mental)
Pujol Nuez, Jesús (Parc de Salut Mar)
Menchón Magriñá, José Manuel (Centro de Investigación Biomédica en Red de Salud Mental)
Ritter, Petra (Max Planck Institut für Kognitions und Neurowissenschaften)
Cardoner, N. (Narcís) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Deco, Gustavo (Institució Catalana de Recerca i Estudis Avançats)

Date:	2016
Abstract:	Resting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS-fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self-referential thoughts and ruminations has made the use of the resting-state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS-fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network. Hum Brain Mapp 37:2918-2930, 2016.
Grants:	European Commission 60402 European Commission 295129 Ministerio de Economía y Competitividad PSI2013-42091-P Instituto de Salud Carlos III CP10/00604
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Mood disorders ; Major depressive disorder ; Dynamic functional connectivity ; Resting state ; Fmri
Published in:	Human brain mapping, Vol. 37, issue 8 (Aug. 2016) , p. 2918-2930, ISSN 1097-0193

DOI: 10.1002/hbm.23215
PMID: 27120982

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