Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome
Kamer, Angela R. (Department of Psychiatry, Center for Brain Health, School of Medicine, New York, NY, USA)
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau)
Videla, Sebastià (Fundació Catalana Síndrome de Down)
Mayoral, Angela (Universitat Internacional de Catalunya. Escola d'Odontologia)
Janal, Malvin (Department of Epidemiology, College of Dentistry, New York University, New York, NY, USA)
Carmona Iragui, María (Fundació Catalana Síndrome de Down)
Benejam, Bessy (Fundació Catalana Síndrome de Down)
Craig, Ronald G. (Department of Basic Sciences and Craniofacial Biology, College of Dentistry, New York University, New York, NY, USA)
Saxena, Deepak (Department of Basic Sciences and Craniofacial Biology, College of Dentistry, New York University, New York, NY, USA)
Corby, Patricia (Department of Psychiatry, Center for Brain Health, School of Medicine, New York, NY, USA)
Glodzik, Lidia (Department of Psychiatry, Center for Brain Health, School of Medicine, New York, NY, USA)
Annam, Kumar Raghava Chowdary (Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY, USA)
Robbins, Miriam (Department of Dental Medicine, Winthrop University Hospital, Mineola, NY, USA)
de Leon, Mony J.. (Department of Psychiatry, Center for Brain Health, School of Medicine, New York, NY, USA)
Universitat Autònoma de Barcelona

Fecha:	2016
Resumen:	People with Down syndrome (DS) are at an increased risk for Alzheimer's disease (AD). After 60 years of age, >50% of DS subjects acquire dementia. Nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. Genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for DS persons at risk for AD. Among them, inflammation, important in AD of DS type, is potential target. Consistent with this hypothesis, chronic peripheral inflammation and infections may contribute to AD pathogenesis in DS. People with DS have an aggressive form of periodontitis characterized by rapid progression, significant bacterial and inflammatory burden, and an onset as early as 6 years of age. This review offers a hypothetical mechanistic link between periodontitis and AD in the DS population. Because periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD.
Nota:	Altres ajuts: This study was supported by National institutes of Health (NIH)/National Institute on Aging grants AG035137, AG032554, AG12101, AG022374, and AG13616, NIH DE023139-02, Alzheimer's Association NIRG-12-173937, and NIH/NCATS UL1 TR000038. Conflict of interest: No conflict of interest is reported for A.R.K., M.J., P.C., R.G.C., D.S., K.R.C.A., M.R., A.M., J.O.F., S.V., M.C.-I., and B.B. M.J. de Leon has a patent on an image analysis technology that was licensed to Abiant Imaging, Inc., by NYU, and has a financial interest in this license agreement, and NYU holds stock options on the company. M. de Leon has received compensation for consulting services from Abiant Imaging. Dr L. Glodzic was a principal investigator on an Investigator-Initiated project funded by Forest Laboratories and received an honorarium for serving as a consultant to Roche Pharma. Contributors: A.R.K., M.J.de.L., and J.F. wrote the manuscript. All the other authors reviewed the manuscript and contributed with the scientific literature, concepts, and modeling. All authors reviewed the manuscript for intellectual content and approved the final draft.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Down syndrome ; Alzheimer's disease ; Infection ; Inflammation ; Dysbiosis ; Periodontal disease ; Aggressive periodontal disease ; Neuroinflammation ; Trisomy 21
Publicado en:	Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 2 (february 2016) , p. 49-57, ISSN 2352-8729

DOI: 10.1016/j.dadm.2016.01.001
PMID: 27239536

9 p, 783.3 KB

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