The Banff 2015 Kidney Meeting Report : Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology
Loupy, Alexandre (Paris Translational Research Center for Organ Transplantation INSERM U970 & Necker Hospital University Paris Descartes)
Haas, Mark (Cedars-Sinai Medical Center)
Solez, Kim (University of Alberta)
Racusen, L. (Johns Hopkins University School of Medicine)
Glotz, Denis (Université Paris VII and INSERM U 1160. Hopital Saint Louis)
Serón Micas, Daniel (Hospital Universitari Vall d'Hebron)
Nankivell, B. J. (Westmead Hospital)
Colvin, Robert (Harvard Medical School)
Afrouzian, Marjan (University of Texas Medical Branch)
Akalin, Enver (Albert Einstein College of Medicine)
Alachkar, Nada (Johns Hopkins University School of Medicine)
Bagnasco, Serena (Johns Hopkins University School of Medicine)
Becker, Jan U (Uniklinik Köln (Colònia, Alemanya))
Cornell, Lynn (Mayo Clinic)
Drachenberg, C. (University of Maryland School of Medicine)
Dragun, Duska (Charité - Universitätsmedizin Berlin)
de Kort, H. (Leiden University Medical Center)
Gibson, I. W. (University of Manitoba)
Kraus, E. S. (Johns Hopkins University School of Medicine)
Lefaucheur, Carmen (Université Paris VII and INSERM U 1160. Hopital Saint Louis)
Legendre, C. (Paris Translational Research Center for Organ Transplantation INSERM U970 & Necker Hospital University Paris Descartes)
Liapis, H. (Washington University)
Muthukumar, T. (New York Presbyterian Hospital-Weill Cornell Medicine)
Nickeleit, V. (University of North Carolina)
Orandi, B. (Johns Hopkins University School of Medicine)
Park, W. (Mayo Clinic)
Rabant, Marion (Université de Paris)
Randhawa, P. (University of Pittsburgh. The Thomas E Starzl Transplantation Institute)
Reed, E. F. (University of California)
Roufosse, C. (Hammersmith Hospital (Londres))
Seshan, S. V. (Weill Cornell Medicine)
Sis, B. (University of Alberta)
Singh, H. K. (University of North Carolina)
Schinstock, C. (Mayo Clinic)
Tambur, Anat R. (Northwestern University. Transplant Immunology Laboratory)
Zeevi, Adriana (University of Pittsburgh Medical Center)
Mengel, Michael (University of Alberta)
Universitat Autònoma de Barcelona

Fecha:	2017
Resumen:	The Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d-negative antibody-mediated rejection () from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor-specific antibody tests (anti- and non-) with transplant histopathology, and questions of molecular transplant diagnostics. The use of transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement the diagnosis and classification of rejection requires further consensus agreement and validation in biopsies. Newly introduced concepts include the i- score, comprising inflammation within areas of fibrosis and atrophy and acceptance of transplant arteriolopathy within the descriptions of chronic active T cell-mediated rejection () or chronic . The pattern of mixed and was increasingly recognized. This report also includes improved definitions of and in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification. The goal of the Banff process is ongoing integration of advances in histologic, serologic, and molecular diagnostic techniques to produce a consensus-based reporting system that offers precise composite scores, accurate routine diagnostics, and applicability to next-generation clinical trials. In this article, the Banff consortium presents the most updated version of the kidney, pancreas, and VCA transplant rejection classification and prospects for implementing intragraft molecular assessment.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Clinical research/practice ; Translational research/science ; Kidney transplantation/nephrology ; Pathology/histopathology ; Organ transplantation in general ; Rejection ; Rejection: antibody-mediated ; Rejection: subclinical ; Rejection: T cell mediated
Publicado en:	American Journal of Transplantation, Vol. 17, Issue 1 (January 2017) , p. 28-41, ISSN 1600-6143

DOI: 10.1111/ajt.14107
PMID: 27862883

14 p, 167.5 KB

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