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Ischemic stroke patients are biologically older than their chronological age
Soriano-Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques)
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques)
Mola-Caminal, Marina (Institut Hospital del Mar d'Investigacions Mèdiques)
Vivanco-Hidalgo, Rosa M. (Institut Hospital del Mar d'Investigacions Mèdiques)
Ois, Angel (Institut Hospital del Mar d'Investigacions Mèdiques)
Rodríguez-Campello, Ana (Institut Hospital del Mar d'Investigacions Mèdiques)
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques)
Sayols-Baixeras, Sergi (Institut Hospital del Mar d'Investigacions Mèdiques)
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques)
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques)
Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona

Date: 2016
Abstract: Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between biological age and actual chronological age would indicate an individual's level of aging. Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age. A total of 123 individuals, 41 controls and 82 patients with ischemic stroke were paired by chronological age, ranging from 39 to 82 years. Illumina HumanMethylation450 BeadChip array was used to measure DNA methylation in CpG sites in both groups, and biological age was estimated using methylation values of specific CpGs. Ischemic stroke patients were biologically an average 2. 5 years older than healthy controls (p-value=0. 010). Stratified by age tertiles, younger stroke patients (≤57 years old) were biologically older than controls (OR=1. 19; 95%CI 1. 00-1. 41, p-value=0. 046). The older groups showed no biological age differences between cases and controls, but were close to reaching the significance level. Ischemic stroke patients are biologically older than controls. Biological age should be considered as a potential new biomarker of stroke risk.
Note: Altres ajuts: This project was funded in part by the following sources: RecerCaixa 2013 research grant (JJ086116).
Note: Número d'acord de subvenció ISCIII/RD12/0042-0020
Note: Número d'acord de subvenció ISCIII/RD12/0042-0013
Note: Número d'acord de subvenció AGAUR/2014 SGR 1213
Note: Número d'acord de subvenció ISCIII/PI12-01238
Note: Número d'acord de subvenció ISCIII/PI15-00451
Note: Número d'acord de subvenció ISCIII/PI15-00445
Note: Número d'acord de subvenció ISCIIIIFI14-00007
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Ischemic stroke ; Aging ; Epigenetics ; Biological age ; DNA methylation
Published in: Aging (Albany NY), Vol. 8 (august 2016) , p. 2655-2665, ISSN 1945-4589

DOI: 10.18632/aging.101028
PMID: 27922817


11 p, 1.1 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-02-07, last modified 2020-11-18



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