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| Home > Articles > Published articles > Ischemic stroke patients are biologically older than their chronological age |
(Institut Hospital del Mar d'Investigacions Mèdiques) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut Hospital del Mar d'Investigacions Mèdiques) (Institut Hospital del Mar d'Investigacions Mèdiques)| Date: | 2016 |
| Abstract: | Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between biological age and actual chronological age would indicate an individual's level of aging. Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age. A total of 123 individuals, 41 controls and 82 patients with ischemic stroke were paired by chronological age, ranging from 39 to 82 years. Illumina HumanMethylation450 BeadChip array was used to measure DNA methylation in CpG sites in both groups, and biological age was estimated using methylation values of specific CpGs. Ischemic stroke patients were biologically an average 2. 5 years older than healthy controls (p-value=0. 010). Stratified by age tertiles, younger stroke patients (≤57 years old) were biologically older than controls (OR=1. 19; 95%CI 1. 00-1. 41, p-value=0. 046). The older groups showed no biological age differences between cases and controls, but were close to reaching the significance level. Ischemic stroke patients are biologically older than controls. Biological age should be considered as a potential new biomarker of stroke risk. |
| Grants: | Instituto de Salud Carlos III RD12/0042-0020 Instituto de Salud Carlos III RD12/0042-0013 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014 SGR 1213 Instituto de Salud Carlos III PI12-01238 Instituto de Salud Carlos III PI15-00451 Instituto de Salud Carlos III PI15-00445 Instituto de Salud Carlos III FI14-00007 |
| Note: | Altres ajuts: This project was funded in part by the following sources: RecerCaixa 2013 research grant (JJ086116). |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Ischemic stroke ; Aging ; Epigenetics ; Biological age ; DNA methylation |
| Published in: | Aging (Albany NY), Vol. 8 (august 2016) , p. 2655-2665, ISSN 1945-4589 |
