Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression : a longitudinal neuroimaging study
Cano, M. (Universitat de Barcelona. Departament de Ciències Clíniques)
Martínez-Zalacaín, I (Hospital Universitari de Bellvitge)
Bernabéu-Sanz, Á (Inscanner SL)
Contreras Rodríguez, Oren (Centro de Investigación Biomédica en Red de Salud Mental)
Hernández-Ribas, R. (Centro de Investigación Biomédica en Red de Salud Mental)
Via, E. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT).)
De Arriba-Arnau, Aida (Hospital Universitari de Bellvitge)
Gálvez, V (School of Psychiatry, University of New South Wales (UNSW) and Black Dog Institute, Randwick, Sydney, Australia)
Urretavizcaya, M. (Centro de Investigación Biomédica en Red de Salud Mental)
Pujol Nuez, Jesús (Hospital del Mar (Barcelona, Catalunya))
Menchón, J. M. (Centro de Investigación Biomédica en Red de Salud Mental)
Cardoner, N. (Narcís) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT).)
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)

Date:	2017
Abstract:	Recent research suggests that neuroplastic and neuroinflammatory changes may account for the mode of action of electroconvulsive therapy (ECT), although extant data do not allow for a clear disambiguation between these two hypotheses. Multimodal neuroimaging approaches (for example, combining structural and metabolic information) may help in clarifying this issue. Here we aimed to assess longitudinal changes in (i) regional gray matter (GM) volumes and (ii) hippocampal metabolite concentrations throughout an acute course of bitemporal ECT, as well as (iii) to determine the association between imaging changes and clinical improvement. We assessed 12 patients with treatment-resistant depression (TRD) at four time points (pre-treatment, after the first ECT session, after the ninth ECT session and 15 days after ECT course completion) and 10 healthy participants at two time points, 5 weeks apart. Patients with TRD showed bilateral medial temporal lobe (MTL) and perigenual anterior cingulate cortex volume increases. Left MTL volume increase was associated with (i) a hippocampal N -acetylaspartate concentration decrease, (ii) a hippocampal Glutamate+Glutamine concentration increase and (iii) significant clinical improvement. The observed findings are, in part, compatible with both neuroplastic and neuroinflammatory changes induced by ECT. We postulate that such phenomena may be interrelated, therefore reconciling the neuroplasticity and neuroinflammatory hypotheses of ECT action.
Grants:	Instituto de Salud Carlos III PS09-01961 Instituto de Salud Carlos III CIBER-CB06-03-0034 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014SGR1672
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Aspartic acid ; Brain ; Case-Control Studies ; Depressive Disorder, Treatment-Resistant ; Electroconvulsive therapy ; Glutamic acid ; Glutamine ; Hippocampus ; Magnetic Resonance Imaging ; Proton Magnetic Resonance Spectroscopy ; Temporal lobe
Published in:	Translational psychiatry, Vol. 7 (02 2017) , p. e1023, ISSN 2158-3188

DOI: 10.1038/tp.2016.267
PMID: 28170003

8 p, 844.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles