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EPICOG-SCH : A brief battery to screen cognitive impact of schizophrenia in stable outpatients
Zaragoza Domingo, Silvia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Bobes, Julio (Psychiatry Department, University of Oviedo, CIBERSAM, Julián Clavería, 6, 33006 Oviedo, Spain)
García-Portilla, Maria-Paz (Psychiatry Department, University of Oviedo, CIBERSAM, Julián Clavería, 6, 33006 Oviedo, Spain)
Morralla, Claudia (Medical Department, Sanofi-Aventis, Josep Pla, 2, 08019 Barcelona, Spain)

Data: 2017
Resum: Brief batteries in schizophrenia, are needed to screen for the cognitive impact of schizophrenia. We aimed to validate and co-norm the Epidemiological Study of Cognitive Impairment in Schizophrenia (EPICOG-SCH) derived brief cognitive battery. A cross-sectional outpatient evaluation was conducted of six-hundred-seventy-two patients recruited from 234 centers. The brief battery included well-known subtests available worldwide that cover cognitive domains related to functional outcomes: WAIS-III-Letter-Number-Sequencing-LNS, Category Fluency Test-CFT, Logical-Memory Immediate Recall-LM, and Digit-Symbol-Coding-DSC. CGI-SCH Severity and WHO-DAS-S were used to assess clinical severity and functional impairment, respectively. Unit Composite Score (UCS) and functional regression-weighted Composite Scores (FWCS) were obtained; discriminant properties of FWCS to identify patients with different levels of functional disability were analyzed using receiver-operating characteristic (ROC) technique. The battery showed good internal consistency, Cronbach's alpha = 0. 78. The differences between cognitive performance across CGI-SCH severity level subscales ranged from 0. 5 to 1 SD. Discriminant capacity of the battery in identifying patients with up to moderate disability levels showed fair discriminant accuracy with areas under the curve (AUC) > 0. 70, p < 0. 0001. An FWCS mean cut-off score ≥ 100 showed likelihood ratios (LR) up to 4. 7, with an LR + of 2. 3 and a LR − of 0. 5. An FWCS cut-off ≥ 96 provided the best balance between sensitivity (0. 74) and specificity (0. 62). The EPICOG-SCH proved to be a useful brief tool to screen for the cognitive impact of schizophrenia, and its regression-weighted Composite Score was an efficient complement to clinical interviews for confirming patients' potential functional outcomes and can be useful for monitoring cognition during routine outpatient follow-up visits.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Publicat a: Schizophrenia Research: Cognition, Vol. 8 (march 2017) , p. 7-20, ISSN 2215-0013

DOI: 10.1016/j.scog.2017.03.001
PMID: 28740826


14 p, 1.1 MB

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