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Specific IgA against Pseudomonas aeruginosa in severe COPD
Millares, Laura (Fundació Parc Taulí. Departament de Pneumologia)
Martí, Sara (Universitat de Barcelona-IDIBELL. Hospital Universitari de Bellvitge. Departament de Microbiologia)
Ardanuy, Carmen (Universitat de Barcelona-IDIBELL. Hospital Universitari de Bellvitge. Departament de Microbiologia)
Liñares, Josefina (Universitat de Barcelona-IDIBELL. Hospital Universitari de Bellvitge. Departament de Microbiologia)
Santos, Salud (Universitat de Barcelona-IDIBELL. Hospital Universitari de Bellvitge. Departament de Pneumologia)
Dorca, Jordi (Universitat de Barcelona-IDIBELL. Hospital Universitari de Bellvitge. Departament de Pneumologia)
García-Nuñez, Marian (Fundació Parc Taulí. Departament de Pneumologia)
Quero, Sara (Institut Germans Trias i Pujol)
Monsó, Eduard (Fundació Parc Taulí. Departament de Pneumologia)

Fecha: 2017
Resumen: The bronchial mucosa is protected by a specialized immune system focused on the prevention of colonization and infection by potentially pathogenic microorganisms (PPMs). Immunoglobulin A (IgA) is the principal antibody involved in this mechanism. A defective immune barrier may facilitate the recurrent presence of PPMs in COPD. The aim of this study was to determine IgA-mediated bronchial specific immune responses against Pseudomonas aeruginosa in stable patients with severe disease. COPD patients with good-quality sputum samples obtained during stability were included and classified according to the presence or absence of chronic bronchial colonization by P. aeruginosa. Levels of specific IgA for P. aeruginosa in sputum were determined by ELISA and expressed as ratios, using the pooled level of 10 healthy subjects as reference (optical density patient/control). Thirty-six stable COPD patients were included, 15 of whom had chronic colonization by P. aeruginosa. Levels of specific IgA against P. aeruginosa in stable non-colonized patients were lower than those in healthy subjects (IgA ratio: median =0. 15 [interquartile range {IQR} 0. 05–0. 36]). Colonized patients had higher levels, (1. 56 [IQR 0. 59–2. 79]) (p 0. 001, Mann–Whitney U test), with figures equivalent but not exceeding the reference value. IgA-based immune response against P. aeruginosa was low in severe COPD patients. Levels of specific IgA against this microorganism were higher in colonized patients, but did not attain clear-cut levels above the reference. An impaired local response against P. aeruginosa may favor chronic colonization and recurrent infections in severe COPD.
Nota: Número d'acord de subvenció FUCAP/FIS/15-00157
Nota: Número d'acord de subvenció CIBERES/CB06/06/0037 i CB06/06/1089
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Immunoglobulin A ; Sputum ; COPD ; Colonization ; ELISA
Publicado en: International Journal of Chronic Obstructive Pulmonary Disease, Vol. 12 (September 2017) , p. 2807-2811, ISSN 1178-2005

PMID: 29033561
DOI: 10.2147/COPD.S141701


Published Version
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El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Artículos > Artículos de investigación
Artículos > Artículos publicados

 Registro creado el 2018-02-08, última modificación el 2019-01-25



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