Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles
Casals, Eudald (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gusta, Muriel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Cobaleda-Siles, Macarena (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Garcia-Sanz, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)

Fecha:	2017
Resumen:	Chemotherapeutic agents have limited efficacy and resistance to them limits today and will limit tomorrow our capabilities of cure. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours. In front of this, multimodality has appeared as a promising strategy to overcome resistance. In this context, the use of nanoparticle-based platforms enables many possibilities to address cancer resistance mechanisms. Nanoparticles can act as carriers and substrates for different ligands and biologically active molecules, antennas for imaging, thermal and radiotherapy and, at the same time, they can be effectors by themselves. This enables their use in multimodal therapies to overcome the wall of resistance where conventional medicine crash as ageing of the population advance. In this work, we review the cancer resistance mechanisms and the advantages of inorganic nanomaterials to enable multimodality against them. In addition, we comment on the need of a profound understanding of what happens to the nanoparticle-based platforms in the biological environment for those possibilities to become a reality.
Ayudas:	European Commission 604387 Ministerio de Ciencia e Innovación FJCI-2015-26832 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-612
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cancer resistance ; Resistance to treatment ; Inorganic nanoparticles ; Multifunctional ; Multimodality
Publicado en:	Cancer Nanotechnology, Vol. 8, issue 1 (2017) , art. 7, ISSN 1868-6966

DOI: 10.1186/s12645-017-0030-4
PMID: 29104700

19 p, 1.2 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
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