The Banff 2017 Kidney Meeting Report : Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials
Haas, Mark (Cedars-Sinai Medical Center)
Loupy, Alexandre (University Paris Descartes. INSERM U970 and Necker Hospital. Paris Translational Research Center for Organ Transplantation)
Lefaucheur, Carmen (Université Paris VII and INSERM U 1160. Hopital Saint Louis)
Roufosse, C. (Imperial College London and North West London Pathology)
Glotz, Denis (Université Paris VII and INSERM U 1160. Hopital Saint Louis)
Serón Micas, Daniel (Hospital Universitari Vall d'Hebron)
Nankivell, B. J. (Westmead Hospital)
Halloran, P. F. (University of Alberta)
Colvin, Robert (Harvard Medical School)
Akalin, Enver (Montefiore Medical Center)
Alachkar, Nada (Johns Hopkins University School of Medicine)
Bagnasco, Serena (Johns Hopkins University School of Medicine)
Bouatou, Y. (Geneva University Hospitals (Suïssa))
Becker, Jan U (Uniklinik Köln (Colònia, Alemanya))
Cornell, Lynn (Mayo Clinic)
van Huyen, J. P. Duong (University Paris Descartes. INSERM U970 and Necker Hospital. Paris Translational Research Center for Organ Transplantation)
Gibson, I. W. (University of Manitoba)
Kraus, Edward S. (Johns Hopkins University)
Mannon, R. B. (University of Alabama School of Medicine)
Naesens, Maarten (University Hospitals Leuven (Bèlgica))
Nickeleit, V. (The University of North Carolina School of Medicine)
Nickerson, P. (University of Manitoba)
Segev, D. L. (Johns Hopkins Medical Institutions)
Singh, H. K. (The University of North Carolina School of Medicine)
Stegall, M. (Mayo Clinic)
Randhawa, P. (University of Pittsburgh)
Racusen, L. (Johns Hopkins University School of Medicine)
Solez, Kim (University of Alberta)
Mengel, Michael (University of Alberta)
Universitat Autònoma de Barcelona

Fecha:	2018
Resumen:	The kidney sessions of the 2017 Banff Conference focused on 2 areas: clinical implications of inflammation in areas of interstitial fibrosis and tubular atrophy (i-) and its relationship to T cell-mediated rejection (), and the continued evolution of molecular diagnostics, particularly in the diagnosis of antibody-mediated rejection (). In confirmation of previous studies, it was independently demonstrated by 2 groups that i- is associated with reduced graft survival. Furthermore, these groups presented that i-, particularly when involving >25% of sclerotic cortex in association with tubulitis, is often a sequela of acute in association with underimmunosuppression. The classification was thus revised to include moderate i- plus moderate or severe tubulitis as diagnostic of chronic active . Other studies demonstrated that certain molecular classifiers improve diagnosis of beyond what is possible with histology, C4d, and detection of donor-specific antibodies () and that both C4d and validated molecular assays can serve as potential alternatives and/or complements to in the diagnosis of . The Banff criteria are thus updated to include these alternatives. Finally, the present report paves the way for the Banff scheme to be part of an integrative approach for defining surrogate endpoints in next-generation clinical trials. The Banff consortium presents revisions to the diagnostic criteria for T cell- and antibody-mediated kidney transplant rejection, including specific criteria for chronic active T cell-mediated rejection, plus prospects for integrative endpoints in clinical trials.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Classification systems: Banff classification ; Kidney transplantation/nephrology ; Molecular biology ; Pathology/histopathology ; Rejection ; Translational research/science
Publicado en:	American Journal of Transplantation, Vol. 18, Issue 2 (February 2018) , p. 293-307, ISSN 1600-6143

DOI: 10.1111/ajt.14625
PMID: 29243394

15 p, 1.1 MB

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