Neuropsychological Outcome One Year after Carotid Revascularization : A before-and-after Study
Casas Hernanz, Laura (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Garolera, Maite (Consorci Sanitari de Terrassa)
Badenes, Dolors (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Quintana, Salvador (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Millán, Susana (Hospital Plató)
Calzado, Noemi (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
de Francisco, Jorge (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Royo, Josep (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Aguilar Barberà, Miquel (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))

Date:	2017
Abstract:	The aim of our study was to determine the clinical profile of patients considered cognitive 'responders' to surgery in order to establish clinical variables associated with a favorable cognitive performance. A total of 70 patients were included in the study. A well-validated, comprehensive standardized neurocognitive battery of tests of about 2 hours was administered. Patients were examined twice, 1-week before surgery and 1-year postoperatively. The criterion to be included in the 'responder' group was the following: to obtain a positive difference between post-revascularization and pre-revascularization neuropsychological assessment ≥1 standard deviation in ≥2 tests. Twenty-seven patients (38. 6%) were cognitive responders to treatment. In bivariate analysis between responders and non-responders, presence of atrophy (P=0. 003), small vessels (P=0. 577), symptoms (P=0. 046), and age (P=0. 030) were the factors statistically significant. When comparing cognitive performance before and after carotid revascularization, significant differences were observed in semantic fluency with a lower performance after 12 months (P=0. 004, d=0. 29), and in the Language index (Repeatable Battery for the Assessment of Neuropsychological Status) (P=0. 005, d=0. 34). Patients without neurological symptoms, of a younger age and without atrophy and white matter small vessel lesions are better cognitive responders 1-year after carotid revascularization.
Note:	Altres ajuts: This study was supported by a grant from the Fundación Mútua Madrileña.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Endarterectomy ; Carotid stenosis ; Angioplasty ; Cognition ; Neuropsychological tests
Published in:	Vascular Specialist International, Vol. 33 (december 2017) , p. 146-155, ISSN 2288-7989

DOI: 10.5758/vsi.2017.33.4.146
PMID: 29354625

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