Web of Science: 4 citas, Scopus: 7 citas, Google Scholar: citas,
The behavioral and psychological symptoms of dementia in Down syndrome (BPSD-DS) scale : comprehensive assessment of psychopathology in Down syndrome
Dekker, Alain D. (Universitair Medisch Centrum Groningen)
Sacco, Silvia (Institut Jérôme Lejeune)
Carfi, Angelo (Universitá Cattolica del Sacro Cuore)
Benejam, Bessy (Fundació Catalana Síndrome de Down)
Vermeiren, Yannick (Universitair Medisch Centrum Groningen)
Beugelsdijk, Gonny (Ipse de Bruggen)
Schippers, Mieke (Ipse de Bruggen)
Hassefras, Lyanne (Ipse de Bruggen)
Eleveld, José (Cosis (Groningen))
Grefelman, Sharina (Cosis (Groningen))
Fopma, Roelie (Talant (Heerenveen))
Bomer-Veenboer, Monique (Pameijer (Rotterdam))
Boti, Mariángeles (Fundació Catalana Síndrome de Down)
Oosterling, G. Danielle E. (Aveleijn (Borne))
Scholten, Esther (Elver (Nieuw-Wehl))
Tollenaere, Marleen (Institute Born-Bunge)
Checkley, Laura (University College London. Division of Psychiatry)
Strydom, André (University College London. Division of Psychiatry)
Van Goethem, Gert (Het GielsBos (Gierle))
Onder, Graziano (Universitá Cattolica del Sacro Cuore)
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau)
zu Eulenburg, Christine (Universitair Medisch Centrum Groningen)
Coppus, Antonia M.W. (Dichterbij (Gennep))
Rebillat, Anne-Sophie (Institut Jérôme Lejeune)
Fortea, Juan (Fundació Catalana Síndrome de Down)
De Deyn, Peter P. (Universitair Medisch Centrum Groningen)
Universitat Autònoma de Barcelona

Fecha: 2018
Resumen: People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated. The central aim was to identify items that change in relation to the dementia status, and thus may differentiate between diagnostic groups. Structured interviews were conducted with informants of persons with DS without dementia (DS, n = 149), with questionable dementia (DS+Q, n = 65), and with diagnosed dementia (DS+AD, n = 67). First exploratory data suggest promising interrater, test-retest, and internal consistency reliability measures. Concerning item relevance, group comparisons revealed pronounced increases in frequency and severity in items of anxiety, sleep disturbances, agitation & stereotypical behavior, aggression, apathy, depressive symptoms, and eating/drinking behavior. The proportion of individuals presenting an increase was highest in DS+AD, intermediate in DS+Q, and lowest in DS. Interestingly, among DS+Q individuals, a substantial proportion already presented increased anxiety, sleep disturbances, apathy, and depressive symptoms, suggesting that these changes occur early in the course of AD. Future efforts should optimize the scale based on current results and clinical experiences, and further study applicability, reliability, and validity. Future application of the scale in daily care may aid caregivers to understand changes, and contribute to timely interventions and adaptation of caregiving.
Nota: Número d'acord de subvenció ISCIII/PI13-01532
Nota: Número d'acord de subvenció ISCIII/PI14-01126
Nota: Número d'acord de subvenció AGAUR/2014/SGR-0235
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Alzheimer's disease ; Behavior ; BPSD ; Dementia ; Down syndrome ; Neuropsychiatric symptoms ; Trisomy 21
Publicado en: Journal of Alzheimer's disease, Vol. 63, issue 2 (2018) , p. 797-819, ISSN 1875-8908

PMID: 29689719
DOI: 10.3233/JAD-170920


23 p, 1.3 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació Biomèdica Sant Pau
Artículos > Artículos de investigación
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 Registro creado el 2018-06-18, última modificación el 2019-12-02



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