Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rueda, Ferran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Oxvig, Claus (Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark)
Oliveras, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Labata, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
De Diego, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ferrer Massot, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Aranda-Nevado, M. Cruz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Serra-Gregori, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Núñez, Julio (Universitat de València. Departament de Medicina)
García, Cosme (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Fecha:	2018
Resumen:	The aim of the present study was to evaluate the prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in patients with ST-segment elevation myocardial infarction (STEMI). Observational cohort study performed in 1085 consecutive STEMI patients treated with early reperfusion between February 2011 and August 2014. Stanniocalcin-2, PAPP-A, and IGFBP-4 were measured using state-of-the art immunoassays. The primary outcome was the composite endpoint of all-cause mortality and readmission due to heart failure (HF). Median follow-up was 3. 3 years (IQR 1. 0-3. 7), during which 176 patients (16. 2%) presented a composite endpoint. Multivariable cox regression analysis revealed that Stanniocalcin-2 (HR 2. 06; 95% CI 1. 13-3. 75; p = 0. 018), IGFBP-4 (HR 1. 73; 95% CI 1. 14-2. 64; p = 0. 010), Killip-Kimball class III-IV (HR 1. 40; 95% CI 1. 13-1. 74; p = 0. 002), NT-ProBNP (HR 1. 21; 95% CI 1. 07-1. 37; p = 0. 002), age (HR 1. 06; 95% CI 1. 04-1. 08; p < 0. 001) and left ventricular ejection fraction (HR 0. 97; 95% CI 0. 95-0. 98; p < 0. 001) were independent predictors of the composite endpoint. A model containing Stanniocalcin-2 and IGFBP-4 on top of clinical variables significantly improved C-index discrimination (p = 0. 036). Stanniocalcin-2 was also identified as independent predictor of all-cause mortality (HR 2. 23; 95% CI 1. 16-4. 29; p = 0. 017) and readmission due to HF (HR 3. 42; 95% CI 1. 22-9. 60; p = 0. 020). In STEMI patients, Stanniocalcin-2 and IGFBP-4 emerged as independent predictors of all-cause death and readmission due to HF. The Stanniocalcin-2/PAPP-A/IGFBP-4 axis exhibits a significant role in STEMI risk stratification.
Ayudas:	Ministerio de Educación y Ciencia SAF2014-59892 Instituto de Salud Carlos III CIBERCV/CB16/11/00403
Nota:	Altres ajuts: Fundació La MARATÓ de TV3 (201502 and 201516)
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	STEMI ; Prognosis ; Stanniocalcin-2 ; PAPP-A ; IGFBP-4
Publicado en:	Cardiovascular diabetology, Vol. 17 (april 2018) , ISSN 1475-2840

DOI: 10.1186/s12933-018-0710-3
PMID: 29712555

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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