Novel approach to continuous adventitious respiratory sound analysis for the assessment of bronchodilator response
Lozano García, Manuel (Institut de Bioenginyeria de Catalunya (IBEC))
Fiz, José Antonio (Institut de Bioenginyeria de Catalunya (IBEC))
Martínez Rivera, Carlos (Universitat Autònoma de Barcelona. Departament de Medicina)
Torrents, Aurora (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ruiz Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Jané, Raimon (Institut de Bioenginyeria de Catalunya (IBEC))

Fecha: 2017
Resumen: Background. A thorough analysis of continuous adventitious sounds (CAS) can provide distinct and complementary information about bronchodilator response (BDR), beyond that provided by spirometry. Nevertheless, previous approaches to CAS analysis were limited by certain methodology issues. The aim of this study is to propose a new integrated approach to CAS analysis that contributes to improving the assessment of BDR in clinical practice for asthma patients. Methods. Respiratory sounds and flow were recorded in 25 subjects, including 7 asthma patients with positive BDR (BDR+), assessed by spirometry, 13 asthma patients with negative BDR (BDR-), and 5 controls. A total of 5149 acoustic components were characterized using the Hilbert spectrum, and used to train and validate a support vector machine classifier, which distinguished acoustic components corresponding to CAS from those corresponding to other sounds. Once the method was validated, BDR was assessed in all participants by CAS analysis, and compared to BDR assessed by spirometry. Results. BDR+ patients had a homogenous high change in the number of CAS after bronchodilation, which agreed with the positive BDR by spirometry, indicating high reversibility of airway obstruction. Nevertheless, we also found an appreciable change in the number of CAS in many BDR- patients, revealing alterations in airway obstruction that were not detected by spirometry. We propose a categorization for the change in the number of CAS, which allowed us to stratify BDR- patients into three consistent groups. From the 13 BDR- patients, 6 had a high response, similar to BDR+ patients, 4 had a noteworthy medium response, and 1 had a low response. Conclusions. In this study, a new non-invasive and integrated approach to CAS analysis is proposed as a high-sensitive tool for assessing BDR in terms of acoustic parameters which, together with spirometry parameters, contribute to improving the stratification of BDR levels in patients with obstructive pulmonary diseases.
Nota: Número d'acord de subvenció AGAUR/2014 SGR 1569
Nota: Número d'acord de subvenció MINECO/DPI2015-68820-R
Nota: IGTP
Nota: Altres ajuts: programa CERCA de la Generalitat de Catalunya
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Publicado en: Plos one, february 2017, p. 1-23



23 p, 4.5 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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 Registro creado el 2018-10-08, última modificación el 2019-01-18



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