Web of Science: 15 citations, Scopus: 16 citations, Google Scholar: citations
Electrochemical Impedance Spectroscopy (bio)sensing through hydrogen evolution reaction induced by gold nanoparticles
Mayorga Martínez, Carmen (Institut Català de Nanociència i Nanotecnologia)
Chamorro García, Alejandro (Institut Català de Nanociència i Nanotecnologia)
Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)

Date: 2015
Abstract: A new gold nanoparticle (AuNP) based detection strategy using Electrochemical Impedance Spectroscopy (EIS) through hydrogen evolution reaction (HER) is proposed. This EIS-HER method is used as an alternative to the conventional EIS based on [Fe(CN)] or [Ru(NH)] indicators. The proposed method is based on the HER induced by AuNPs. EIS measurements for different amounts of AuNP are registered and the charge transfer resistance (R) was found to correlate and be useful for their quantification. Moreover the effect of AuNP size on electrical properties of AuNPs for HER using this sensitive technique has been investigated. Different EIS-HER signals generated in the presence of AuNPs of different sizes (2, 5, 10, 15, 20, and 50nm) are observed, being the corresponding phenomena extendible to other nanoparticles and related catalytic reactions. This EIS-HER sensing technology is applied to a magneto-immunosandwich assay for the detection of a model protein (IgG) achieving improvements of the analytical performance in terms of a wide linear range (2-500ngmL) with a good limit of detection (LOD) of 0. 31ngmL and high sensitivity. Moreover, with this methodology a reduction of one order of magnitude in the LOD for IgG detection, compared with a chroamperometric technique normally used was achieved.
Note: Número d'acord de subvenció MINECO/MAT2011-25870
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès.
Document: article ; recerca ; acceptedVersion
Subject: Electrochemical Impedance Spectroscopy ; Gold nanoparticles ; Hydrogen evolution reaction ; Magneto-immunoassay
Published in: Biosensors and Bioelectronics, Vol. 67 (May 2015) , p. 53-58, ISSN 1873-4235

DOI: 10.1016/j.bios.2014.05.066


Postprint
19 p, 664.0 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2018-12-19, last modified 2019-02-13



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