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Survival curves and behavioral profiles of female 3xTg-AD mice surviving to 18-months of age as compared to mice with normal aging
Torres-Lista, Virginia (Universitat Autònoma de Barcelona. Institut de Neurociències)
De la Fuente, Mónica (Universidad Complutense de Madrid. Departamento de Fisiología Animal II)
Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)

Fecha: 2017
Resumen: New evidence reveals a high degree of heterogeneity in Alzheimer's disease (AD) clinical and temporal patterns, supporting the existence of several subgroups of patients. Prognosticators of end-of-life dementia specific to elderly patients are necessary to address this heterogeneity. Among 3xTg-AD mice, a widely-used model for AD, a very small number of animals overcome advanced neuropathological stages of disease beyond 18 months of age. They are usually females, which reach longevity in spite of worse neuropathological status as compared to males (the morbidity/mortality paradox). We posit that 3xTg-AD long-term survivors could serve to model end-of-life dementia but also aware about the mortality selection bias. In the present study, we performed behavioral and functional phenotype in long-term survivors, 18-month-old female 3xTg-AD mice and age-matched wildtype undergoing normal aging. Animals were followed up until natural death to correlate survival with phenotype assessments. Strong similarity of their behavioral profiles in all the variables analyzed (e. g. reflexes, sensorimotor functions, locomotion, exploration, emotionality, and anxiety-like behaviors) was found, with the exception of memory impairment, which was a salient trait in old 3xTg-AD survivors. The two groups showed similar mean life expectancy and had behavioral correlates among lifespan, neophobia and long-term memory in common, with some distinctions in 3xTg-AD, supporting recent studies in end-of-life patients. In spite of the small sample size, this brief report presents an interesting scenario to further study heterogeneity and survival in Alzheimer's disease. 3xTg-AD survivors may be a model to gain insight into the frailty/survival paradigm in normal and pathological aging.
Nota: Número d'acord de subvenció ISCIII/PI15/01787
Nota: Número d'acord de subvenció ISCIII/PI107/0283
Nota: Número d'acord de subvenció ISCIII/RD12-0043-0018
Derechos: This is an open access article distributed under the terms of the , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Creative Commons
Lengua: Anglès
Documento: article ; recerca ; publishedVersion
Materia: Alzheimer's disease ; Animal model ; Behavioral correlates ; End-of-life ; Frailty ; Heterogeneity ; Survivorship
Publicado en: Journal of Alzheimer's disease reports, Vol. 1, issue 1 (2017) , p. 47-57, ISSN 2542-4823

DOI: 10.3233/ADR-170011
PMID: 30480229

11 p, 334.7 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Neurociències (INc)
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 Registro creado el 2018-12-31, última modificación el 2020-08-08

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