Web of Science: 0 citas, Scopus: 0 citas, Google Scholar: citas,
Two different strategies to enhance osseointegration in porous titanium : Inorganic thermo-chemical treatment versus organic coating by peptide adsorption
Ortiz-Hernandez, Monica (Universitat Politècnica de Catalunya. Barcelona Research Center in Multiscale Science and Engineering)
Rappe, Katrin Steffanie (Universitat Autònoma de Barcelona. Departament de Cirugia Animal)
Molmeneu, Meritxell (Universitat Politècnica de Catalunya. Barcelona Research Center in Multiscale Science and Engineering)
Mas-Moruno, Carles (Universitat Politècnica de Catalunya. Barcelona Research Center in Multiscale Science and Engineering)
Guillem-Marti, Jordi (Universitat Politècnica de Catalunya. Barcelona Research Center in Multiscale Science and Engineering)
Punset, Miquel (Universitat Politècnica de Catalunya. Barcelona Research Center in Multiscale Science and Engineering)
Caparros, Cristina (Universitat Politècnica de Catalunya. Barcelona Research Center in Multiscale Science and Engineering)
Calero, Jose (Universitat Politècnica de Catalunya. Biomaterials Biomechanics and Tissue Engineering Group (BBT). Department of Materials Science and Metallurgical Engineering)
Franch Serracanta, Jordi (Universitat Autònoma de Barcelona. Departament de Cirugia Animal)
Fernandez-Fairen, Mariano (Universidad Internacional de Cataluña. Facultad de Odontología. Campus de Medicina y Ciencias de la Salud)
Gil, Javier (Universidad Internacional de Cataluña. Facultad de Odontología. Campus de Medicina y Ciencias de la Salud)

Fecha: 2018
Resumen: In this study, highly-interconnected porous titanium implants were produced by powder sintering with different porous diameters and open interconnectivity. The actual foams were produced using high cost technologies: Chemical Vapor Deposition (CVD), Physical Vapor Deposition (PVD), and spark plasma sintering, and the porosity and/or interconnection was not optimized. The aim was to generate a bioactive surface on foams using two different strategies, based on inorganic thermo-chemical treatment and organic coating by peptide adsorption, to enhance osseointegration. Porosity was produced using NaCl as a space holder and polyethyleneglicol as a binder phase. Static and fatigue tests were performed in order to determine mechanical behaviors. Surface bioactivation was performed using a thermo-chemical treatment or by chemical adsorption with peptides. Osteoblast-like cells were cultured and cytotoxicity was measured. Bioactivated scaffolds and a control were implanted in the tibiae of rabbits. Histomorphometric evaluation was performed at 4 weeks after implantation. Interconnected porosity was 53% with an average diameter of 210 µm and an elastic modulus of around 1 GPa with good mechanical properties. The samples presented cell survival values close to 100% of viability. Newly formed bone was observed inside macropores, through interconnected porosity, and on the implant surface. Successful bone colonization of inner structure (40%) suggested good osteoconductive capability of the implant. Bioactivated foams showed better results than non-treated ones, suggesting both bioactivation strategies induce osteointegration capability.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Materia: Titanium foams ; Osseointegration ; Porosity ; Bioactive materials
Publicado en: International Journal of Molecular Sciences, Vol. 19 Núm. 9 (september 2018) , p. 2574, ISSN 1422-0067

DOI: 10.3390/ijms19092574
PMID: 30200178


17 p, 3.8 MB

El registro aparece en las colecciones:
Artículos > Artículos de investigación
Artículos > Artículos publicados

 Registro creado el 2019-01-16, última modificación el 2019-04-08



   Favorit i Compartir