Web of Science: 2 citations, Scopus: 2 citations, Google Scholar: citations,
The genome-wide associated candidate gene ZNF804A and psychosis-proneness : evidence of sex-modulated association
De Castro-Catala, Marta (Institut de Biomedicina de la Universitat de Barcelona (IBUB))
Mora-Solano, Aurea (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)
Kwapil, Thomas R. (Department of Psychology, University of Illinois at Champaign-Urbana)
Cristóbal Narváez, Paula (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Sheinbaum Frank, Tamara (Universitat Autònoma de Barcelona. Departament de Psicología Clínica i de la Salut)
Racioppi, Anna (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Barrantes Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Rosa, Araceli (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)

Date: 2017
Abstract: BACKGROUND: The Zinc finger protein 804A (ZNF804A) is a promising candidate gene for schizophrenia and the broader psychosis phenotype that emerged from genome-wide association studies. It is related to neurodevelopment and associated to severe symptoms of schizophrenia and alterations in brain structure, as well as positive schizotypal personality traits in non-clinical samples. Moreover, a female-specific association has been observed between ZNF804A and schizophrenia. AIM: The present study examined the association of two ZNF804A polymorphisms (rs1344706 and rs7597593) with the positive dimension of schizotypy and psychotic-like experiences in a sample of 808 non-clinical subjects. Additionally, we wanted to explore whether the sexual differences reported in schizophrenia are also present in psychosis-proneness. RESULTS: Our results showed an association between rs7597593 and both schizotypy and psychotic-like experiences. These associations were driven by females, such those carrying the C allele had higher scores in the positive dimension of both variables compared to TT allele homozygotes. CONCLUSION: The findings of the present study support the inclusion of ZNF804 variability in studies of the vulnerability for the development of psychopathology in non-clinical samples and consideration of sex as a moderator of this association.
Note: Número d'acord de subvenció MINECO/PSI2011-30321-C02-01
Note: Número d'acord de subvenció MINECO/PSI2011-30321-C02-02
Note: Número d'acord de subvenció MINECO/PSI2014-54009-R
Note: Número d'acord de subvenció MINECO/PSI2014-56303-REDT-PROMOSAM
Note: Número d'acord de subvenció AGAUR/2014/SGR1070
Note: Número d'acord de subvenció AGAUR/2014/SGR1636
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Adult ; Female ; Genetic predisposition to disease ; Genome-wide association study ; Humans ; Kruppel-like transcription factors ; Male ; Polymorphism ; Single nucleotide ; Psychotic disorders ; Schizophrenia ; Sex factors
Published in: PLoS ONE, Vol. 12, núm. 9 (2017) , p. e0185072, ISSN 1932-6203

DOI: 10.1371/journal.pone.0185072
PMID: 28931092


11 p, 955.3 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2019-01-18, last modified 2019-01-28



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