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Pàgina inicial > Articles > Articles publicats > The genome-wide associated candidate gene ZNF804A and psychosis-proneness : |
Data: | 2017 |
Resum: | BACKGROUND: The Zinc finger protein 804A (ZNF804A) is a promising candidate gene for schizophrenia and the broader psychosis phenotype that emerged from genome-wide association studies. It is related to neurodevelopment and associated to severe symptoms of schizophrenia and alterations in brain structure, as well as positive schizotypal personality traits in non-clinical samples. Moreover, a female-specific association has been observed between ZNF804A and schizophrenia. AIM: The present study examined the association of two ZNF804A polymorphisms (rs1344706 and rs7597593) with the positive dimension of schizotypy and psychotic-like experiences in a sample of 808 non-clinical subjects. Additionally, we wanted to explore whether the sexual differences reported in schizophrenia are also present in psychosis-proneness. RESULTS: Our results showed an association between rs7597593 and both schizotypy and psychotic-like experiences. These associations were driven by females, such those carrying the C allele had higher scores in the positive dimension of both variables compared to TT allele homozygotes. CONCLUSION: The findings of the present study support the inclusion of ZNF804 variability in studies of the vulnerability for the development of psychopathology in non-clinical samples and consideration of sex as a moderator of this association. |
Ajuts: | Ministerio de Economía y Competitividad PSI2011-30321-C02-01 Ministerio de Economía y Competitividad PSI2011-30321-C02-02 Ministerio de Economía y Competitividad PSI2014-54009-R Ministerio de Economía y Competitividad PSI2014-56303-REDT Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR1070 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR1636 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Adult ; Female ; Genetic predisposition to disease ; Genome-wide association study ; Humans ; Kruppel-like transcription factors ; Male ; Polymorphism ; Single nucleotide ; Psychotic disorders ; Schizophrenia ; Sex factors |
Publicat a: | PloS one, Vol. 12, núm. 9 (2017) , p. e0185072, ISSN 1932-6203 |
11 p, 955.3 KB |