Web of Science: 14 cites, Scopus: 16 cites, Google Scholar: cites,
Airborne copper exposure in school environments associated with poorer motor performance and altered basal ganglia
Pujol Nuez, Jesús (Centro de Investigación Biomédica en Red Salud Mental (CIBERSAM))
Fenoll, Raquel (Hospital del Mar)
Macià, Dídac (Hospital del Mar)
Martínez Vilavella, Gerard (Hospital del Mar)
Álvarez Pedrerol, Mar (Ciber on Epidemiology and Public Health (CIBERESP))
Rivas Lara, Ioar (Institut de Diagnosi Ambiental i Estudis de l'Aigua)
Forns, Joan (Ciber on Epidemiology and Public Health (CIBERESP))
Deus Yela, Juan (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Blanco Hinojo, Laura (Hospital del Mar)
Querol Carceller, Xavier (Institut de Diagnosi Ambiental i Estudis de l'Aigua)
Sunyer Deu, Jordi (IMIM (Hospital del Mar))

Data: 2016
Resum: Children are more vulnerable to the effects of environmental elements. A variety of air pollutants are among the identified factors causing neural damage at toxic concentrations. It is not obvious, however, to what extent the tolerated high levels of air pollutants are able to alter brain development. We have specifically investigated the neurotoxic effects of airborne copper exposure in school environments. Speed and consistency of motor response were assessed in 2836 children aged from 8 to 12 years. Anatomical , diffusion tensor imaging, and functional were used to directly test the brain repercussions in a subgroup of 263 children. Higher copper exposure was associated with poorer motor performance and altered structure of the basal ganglia. Specifically, the architecture of the caudate nucleus region was less complete in terms of both tissue composition and neural track water diffusion. Functional consistently showed a reciprocal connectivity reduction between the caudate nucleus and the frontal cortex. The results establish an association between environmental copper exposure in children and alterations of basal ganglia structure and function.
Nota: Número d'acord de subvenció EC/FP7/268479
Nota: Número d'acord de subvenció AGAUR/2014/SGR-1673
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Air pollution ; Brain development ; Copper ; Diffusion tensor imaging ; Neurodegenerative disorders
Publicat a: Brain and behavior, Vol. 6, Issue 6 (June 2016) , art. e00467, ISSN 2162-3279

PMID: 27134768
DOI: 10.1002/brb3.467


13 p, 1.3 MB

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 Registre creat el 2019-01-28, darrera modificació el 2019-11-06



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