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Long-term functionality of transversal intraneural electrodes is improved by dexamethasone treatment
de la Oliva, N. (Universitat Autònoma de Barcelona. Institut de Neurociències)
del Valle Macià, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències)
Delgado Martínez, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències)
Mueller, M (Albert Ludwig University Freiburg. Laboratory for Biomedical Microtechnology)
Stieglitz, T (Albert Ludwig University Freiburg. Laboratory for Biomedical Microtechnology)
Navarro Acebes, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències)

Fecha: 2019
Resumen: Neuroprostheses aimed to restore lost functions after a limb amputation are based on the interaction with the nervous system by means of neural interfaces. Among the different designs, intraneural electrodes implanted in peripheral nerves represent a good strategy to stimulate nerve fibers to send sensory feedback and to record nerve signals to control the prosthetic limb. However, intraneural electrodes, as any device implanted in the body, induce a foreign body reaction (FBR) that results in the tissue encapsulation of the device. The FBR causes a progressive decline of the electrode functionality over time due to the physical separation between the electrode active sites and the axons to interface. Modulation of the inflammatory response has arisen as a good strategy to reduce the FBR and maintain electrode functionality. In this study transversal intraneural multi-channel electrodes (TIMEs) were implanted in the rat sciatic nerve and tested for 3 months to evaluate stimulation and recording capabilities under chronic administration of dexamethasone. Dexamethasone treatment significantly reduced the threshold for evoking muscle responses during the follow-up compared to saline-treated animals, without affecting the selectivity of stimulation. However, dexamethasone treatment did not improve the signal-to-noise ratio of the recorded neural signals. Dexamethasone treatment allowed to maintain more working active sites along time than saline treatment. Thus, systemic administration of dexamethasone appears as a useful treatment in chronically implanted animals with neural electrodes as it increases the number of functioning contacts of the implanted TIME and reduces the intensity needed to stimulate the nerve.
Nota: Altres ajuts: Fundación Ramón Areces (CIVP18A3897)i CERCA Programme/Generalitat de Catalunya.
Nota: Número d'acord de subvenció EC/FP7-611687
Nota: Número d'acord de subvenció EC/FP7-602547
Nota: Número d'acord de subvenció EC/H2020/785219
Nota: Número d'acord de subvenció ISCII/TERCEL/RD12/0019/0011
Nota: Número d'acord de subvenció ISCII/CIBERNED/CB06/05/1105
Nota: Número d'acord de subvenció MINECO/SEV-2013-0295
Derechos: Tots els drets reservats
Lengua: Anglès.
Documento: article ; recerca ; acceptedVersion
Materia: Dexamethasone ; Foreign body reaction ; Intraneural electrode ; Neuroprosthesis ; Stimulation
Publicado en: IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2019 , ISSN 1534-4320

DOI: 10.1109/TNSRE.2019.2897256


9 p, 973.4 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Neurociències (INc)
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 Registro creado el 2019-02-14, última modificación el 2019-04-24



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