Web of Science: 4 citations, Scopus: 4 citations, Google Scholar: citations,
Postepizootic Persistence of Asymptomatic Mycoplasma conjunctivae Infection in Iberian Ibex
Fernández-Aguilar, Xavier (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Cabezón, Oscar (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Granados, José Enrique (Espacio Natural Sierra Nevada)
Frey, Joachim (University of Bern. Institute of Veterinary Bacteriology)
Serrano Ferron, Emmanuel (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Velarde, Roser (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Cano-Manuel, Francisco Javier (Espacio Natural Sierra Nevada)
Mentaberre, Gregorio (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Ráez-Bravo, Arián (Espacio Natural Sierra Nevada)
Fandos, Paulino (Parque Natural Sierras de Cazorla, Segura y Las Villas)
López-Olvera, Jorge Ramón (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)

Date: 2017
Abstract: The susceptibility of the Iberian ibex (Capra pyrenaica) to Mycoplasma conjunctivae ocular infection and the changes in their interaction over time were studied in terms of clinical outcome, molecular detection, and IgG immune response in a captive population that underwent a severe infectious keratoconjunctivitis (IKC) outbreak. Mycoplasma conjunctivae was detected in the Iberian ibex, coinciding with the IKC outbreak. Its prevalence had a decreasing trend in 2013 that was consistent with the clinical resolution (August, 35. 4%; September, 8. 7%; November, 4. 3%). Infections without clinical outcome were, however, still detected in the last handling in November. Sequencing and cluster analyses of the M. conjunctivae strains found 1 year later in the ibex population confirmed the persistence of the same strain lineage that caused the IKC outbreak but with a high prevalence (75. 3%) of mostly asymptomatic infections and with lower DNA load of M. conjunctivae in the eyes (mean quantitative PCR [qPCR] cycle threshold [CT], 36. 1 versus 20. 3 in severe IKC). Significant age-related differences of M. conjunctivae prevalence were observed only under IKC epizootic conditions. No substantial effect of systemic IgG on M. conjunctivae DNA in the eye was evidenced with a linear mixed-models selection, which indicated that systemic IgG does not necessarily drive the resolution of M. conjunctivae infection and does not explain the epidemiological changes observed. The results show how both epidemiological scenarios, i. e. , severe IKC outbreak and mostly asymptomatic infections, can consecutively occur by entailing mycoplasma persistence.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Asymptomatic infection ; Capra pyrenaica ; Iberian ibex ; Infectious keratoconjunctivitis ; Host-pathogen interactions ; Infection persistence ; Molecular epidemiology ; Virulence
Published in: Applied and Environmental Microbiology, Vol. 83 Núm. 15 (2017)

DOI: 10.1128/AEM.00690-17
PMID: 28526790


15 p, 2.1 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2019-02-25, last modified 2019-03-21



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