Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection
Almansa, Raquel (Hospital Clínico Universitario de Valladolid)
Martínez-Orellana, Pamela (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Rico, Lucía (Hospital Clínico Universitario de Valladolid)
Iglesias, Verónica (Hospital Clínico Universitario de Valladolid)
Ortega, Alicia (Hospital Clínico Universitario de Valladolid)
Vidaña, Beatriz (Animal and Plant Health Agency (Surrey, Regne Unit))
Martínez Martínez, Jorge (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Expósito, Ana (Hospital Clínico Universitario de Valladolid)
Montoya, Maria (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Bermejo-Martin, Jesus F. (Hospital Clínico Universitario de Valladolid)

Fecha:	2017
Resumen:	Background: The interaction between influenza virus and the host response to infection clearly plays an important role in determining the outcome of infection. While much is known on the participation of inflammation on the pathogenesis of severe A (H1N1) pandemic 09-influenza virus, its role in the course of non-fatal pneumonia has not been fully addressed. Methods: A systems biology approach was used to define gene expression profiles, histology and viral dynamics in the lungs of healthy immune-competent mice with pneumonia caused by a human influenza A (H1N1) pdm09 virus, which successfully resolved the infection. Results: Viral infection activated a marked pro-inflammatory response at the lung level paralleling the emergence of histological changes. Cellular immune response and cytokine signaling were the two signaling pathway categories more representative of our analysis. This transcriptome response was associated to viral clearance, and its resolution was accompanied by resolution of histopathology. Discussion: These findings suggest a dual role of pulmonary inflammation in viral clearance and development of pneumonia during non-fatal infection caused by the 2009 pandemic influenza virus. Understanding the dynamics of the host's transcriptomic and virological changes over the course of the infection caused by A (H1N1) pdm09 virus may help identifying the immune response profiles associated with an effective response against influenza virus.
Ayudas:	Instituto de Salud Carlos III GR09/0021
Nota:	Altres ajuts: BBSRC/BBS/E/I/00002014
Nota:	Altres ajuts: Programa para/EMER07/050
Nota:	Altres ajuts: BBSRC/BBS/E/I/00002014
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Gene expression ; Immune response ; Inflammation ; Influenza ; Lung ; Mice model
Publicado en:	PeerJ, Vol. 5 (October 2017) , art. e3915, ISSN 2167-8359

DOI: 10.7717/peerj.3915
PMID: 29038764

20 p, 11.0 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
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