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Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection
Almansa, Raquel (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis)
Martínez-Orellana, Pamela (Universitat Autónoma de Barcelona. Centre de Recerca en Sanitat Animal)
Rico, Lucía (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis)
Iglesias, Verónica (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis)
Ortega, Alicia (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis)
Vidaña, Beatriz (Department of Pathology. Animal and Plant Health Agency)
Martínez Martínez, Jorge (Universitat Autónoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Expósito, Ana (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis)
Montoya, María (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal)
Bermejo-Martin, Jesús F. (Hospital Clínico Universitario de Valladolid. Laboratory of Biomedical Research in Sepsis)

Fecha: 2017
Resumen: Background: The interaction between influenza virus and the host response to infection clearly plays an important role in determining the outcome of infection. While much is known on the participation of inflammation on the pathogenesis of severe A (H1N1) pandemic 09-influenza virus, its role in the course of non-fatal pneumonia has not been fully addressed. Methods: A systems biology approach was used to define gene expression profiles, histology and viral dynamics in the lungs of healthy immune-competent mice with pneumonia caused by a human influenza A (H1N1) pdm09 virus, which successfully resolved the infection. Results: Viral infection activated a marked pro-inflammatory response at the lung level paralleling the emergence of histological changes. Cellular immune response and cytokine signaling were the two signaling pathway categories more representative of our analysis. This transcriptome response was associated to viral clearance, and its resolution was accompanied by resolution of histopathology. Discussion: These findings suggest a dual role of pulmonary inflammation in viral clearance and development of pneumonia during non-fatal infection caused by the 2009 pandemic influenza virus. Understanding the dynamics of the host's transcriptomic and virological changes over the course of the infection caused by A (H1N1) pdm09 virus may help identifying the immune response profiles associated with an effective response against influenza virus.
Nota: Número d'acord de subvenció BBSRC/BBS/E/I/00002014
Nota: Número d'acord de subvenció Programa para/EMER07/050
Nota: Número d'acord de subvenció ISCIII/GR09/0021
Nota: Número d'acord de subvenció BBSRC/BBS/E/I/00002014
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglés.
Documento: article ; recerca ; publishedVersion
Materia: Gene expression ; Immune response ; Inflammation ; Influenza ; Lung ; Mice model
Publicado en: PeerJ, Vol. 2017, Núm. 10 (2017) , p. e3915, ISSN 2167-8359

DOI: 10.7717/peerj.3915
PMID: 29038764


20 p, 11.0 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
Artículos > Artículos de investigación
Artículos > Artículos publicados

 Registro creado el 2019-04-02, última modificación el 2019-04-29



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