Web of Science: 14 citations, Scopus: 13 citations, Google Scholar: citations,
Carbon nanotubes allow capture of krypton, barium and lead for multichannel biological X-ray fluorescence imaging
Serpell, Christopher J. (University of Kent)
Rutte, Reida N. (University of Oxford)
Geraki, Kalotina (Harwell Science and Innovation Campus)
Pach, Elzbieta (Institut Català de Nanociència i Nanotecnologia)
Martincic, Markus (Institut de Ciencia de Materials de Barcelona)
Kierkowicz, Magdalena (Institut de Ciència de Materials de Barcelona)
De Munari, Sonia (University of Oxford)
Wals, Kim (University of Oxford)
Raj, Ritu (University of Oxford)
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia)
Tobias, Gerard (Institut de Ciencia de Materials de Barcelona)
Anthony, Daniel C. (University of Oxford)
Davis, Benjamin G. (University of Oxford)

Date: 2016
Abstract: The desire to study biology in situ has been aided by many imaging techniques. Among these, X-ray fluorescence (XRF) mapping permits observation of elemental distributions in a multichannel manner. However, XRF imaging is underused, in part, because of the difficulty in interpreting maps without an underlying cellular 'blueprint'; this could be supplied using contrast agents. Carbon nanotubes (CNTs) can be filled with a wide range of inorganic materials, and thus can be used as 'contrast agents' if biologically absent elements are encapsulated. Here we show that sealed single-walled CNTs filled with lead, barium and even krypton can be produced, and externally decorated with peptides to provide affinity for sub-cellular targets. The agents are able to highlight specific organelles in multiplexed XRF mapping, and are, in principle, a general and versatile tool for this, and other modes of biological imaging.
Note: Número d'acord de subvenció EC/FP7/290023
Note: Número d'acord de subvenció MINECO/SEV-2013-0295
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Barium ; Feasibility Studies ; Fluorescence ; Krypton ; Lead ; Nanotubes ; Peptides ; Spectrometry
Published in: Nature communications, Vol. 7 (October 2016) , art. 13118, ISSN 2041-1723

DOI: 10.1038/ncomms13118
PMID: 27782209


10 p, 1.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2019-06-03, last modified 2019-09-30



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