Web of Science: 24 citas, Scopus: 25 citas, Google Scholar: citas,
Carboxyl group (-CO2H) functionalized coordination polymer nanoparticles as efficient platforms for drug delivery
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia)
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Nador, Fabiana (Institut Català de Nanociència i Nanotecnologia)
Wnuk, Karolina (Institut Català de Nanociència i Nanotecnologia)
Ruiz Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)

Fecha: 2014
Resumen: Functionalization of nanoparticles can significantly influence their properties and potential applications. Although researchers can now functionalize metal, metal oxide, and organic polymer nanoparticles with a high degree of precision, controlled surface functionalization of nanoscale coordination polymer particles (CPPs) has remained a significant challenge. The lack of methodology is perhaps one of the greatest roadblocks to the advancement of CPPs into high added-value drug delivery applications. Here, we report having achieved this goal through a stepwise formation and functionalization protocol. We fabricated robust nanoparticles with enhanced thermal and colloidal stabilities by incorporation of carboxyl groups and these surface carboxyl groups could be subsequently functionalized through well-known peptide coupling reactions. The set of chemistries that we employed as proof-of-concept enabled a plethora of new functional improvements for the application of CPPs as drug delivery carriers, including enhanced colloidal stabilities and the incorporation of additional functional groups such as polyethylene glycol (PEG) or fluorescent dyes that enabled tracking of their cellular uptake. Finally, we ascertained the cytotoxicity of the new CPP nanoparticles loaded with camptothecin to human breast adenocarcinoma (MCF-7). Efflux measurements show that the encapsulation of camptothecin enhances the potency of the drug 6. 5-fold and increases the drug retention within the cell. Multifunctional CPPs: Robust and biocompatible coordination polymer nanoparticles (CPPs) with enhanced thermal and colloidal stabilities were obtained by incorporation of carboxyl groups on the amorphous structure. The surface carboxyl groups can be subsequently functionalized, generating a multifunctional nanoplatform for theranostic applications such as drug delivery and imaging (see scheme; EDC=1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; NHS=N-hydroxysuccinimide).
Nota: Número d'acord de subvenció MINECO/MAT2012-38318-C03-02
Nota: Número d'acord de subvenció MINECO/JCI‐2011–09239
Derechos: Tots els drets reservats.
Lengua: Anglès.
Documento: article ; recerca ; submittedVersion
Materia: Catechol ; Coordination polymers ; Drug delivery ; Nanoparticles ; Surface functionalization
Publicado en: Chemistry - a European journal, Vol. 20, Issue 47 (November 2014) , p. 15443-15450, ISSN 1521-3765

DOI: 10.1002/chem.201403441

9 p, 803.1 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
Artículos > Artículos de investigación
Artículos > Artículos publicados

 Registro creado el 2019-06-12, última modificación el 2019-07-08

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