Web of Science: 18 citations, Scopus: 19 citations, Google Scholar: citations,
Encapsulation and release mechanisms in coordination polymer nanoparticles
Amorín Ferré, Laura (Universitat Autònoma de Barcelona. Departament de Química)
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química)
Bourdelande, J. L. (José Luis) (Universitat Autònoma de Barcelona. Departament de Química)
Ruiz Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Hernando Campos, Jordi (Universitat Autònoma de Barcelona. Departament de Química)
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia)

Date: 2013
Abstract: The interplay of guest encapsulation and release mechanisms in nanoscale metal-organic vehicles and its effect on the drug-delivery kinetics of these materials were investigated through a new multidisciplinary approach. Two rationally-designed molecular guests were synthesized, which consist of a red-fluorescent benzophenoxazine dye covalently tethered to a coordinating catechol group and a protected, non-coordinating catechol moiety. This allowed loading of the guests into compositionally and structurally equivalent coordination polymer particles through distinct encapsulation mechanisms: coordination and mechanical entrapment. The two types of particles delivered their fluorescent cargo with remarkably different kinetic profiles, which could be satisfactorily modeled considering degradation- and diffusion-controlled release processes. This demonstrates that careful selection of the method of guest incorporation into coordination polymer nanoparticles allows selective tuning of the rate of drug delivery from these materials and, therefore, of the time window of action of the encapsulated therapeutic agents. Drug-release mechanisms uncovered! Coordination polymer nanoparticles loaded with coordinated and mechanically entrapped fluorescent guests were prepared as benchmark systems to investigate diffusion- and degradation-controlled drug delivery from these materials (see figure).
Note: Número d'acord de subvenció MINECO/MAT2012–38318‐C03–02
Note: Número d'acord de subvenció MINECO/MAT2012–38319‐C02–01
Note: Número d'acord de subvenció MINECO/CTQ2012–30853
Note: Número d'acord de subvenció MINECO/CTQ2010–15380
Note: Número d'acord de subvenció MINECO/JCI‐2011–09239
Rights: Tots els drets reservats.
Language: Anglès.
Document: article ; recerca ; submittedVersion
Subject: Drug delivery ; Fluorescence ; Metal-organic frameworks ; Nanoparticles ; Polymers
Published in: Chemistry - A European journal, Vol. 19, Issue 51 (December 2013) , p. 17508-17516, ISSN 1521-3765

DOI: 10.1002/chem.201302662


Preprint
13 p, 1.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2019-06-12, last modified 2019-07-11



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