Web of Science: 27 cites, Scopus: 31 cites, Google Scholar: cites,
Encapsulation and release mechanisms in coordination polymer nanoparticles
Amorín Ferré, Laura (Universitat Autònoma de Barcelona. Departament de Química)
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química)
Bourdelande, J. L. (José Luis) (Universitat Autònoma de Barcelona. Departament de Química)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Hernando Campos, Jordi (Universitat Autònoma de Barcelona. Departament de Química)
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia)

Data: 2013
Resum: The interplay of guest encapsulation and release mechanisms in nanoscale metal-organic vehicles and its effect on the drug-delivery kinetics of these materials were investigated through a new multidisciplinary approach. Two rationally-designed molecular guests were synthesized, which consist of a red-fluorescent benzophenoxazine dye covalently tethered to a coordinating catechol group and a protected, non-coordinating catechol moiety. This allowed loading of the guests into compositionally and structurally equivalent coordination polymer particles through distinct encapsulation mechanisms: coordination and mechanical entrapment. The two types of particles delivered their fluorescent cargo with remarkably different kinetic profiles, which could be satisfactorily modeled considering degradation- and diffusion-controlled release processes. This demonstrates that careful selection of the method of guest incorporation into coordination polymer nanoparticles allows selective tuning of the rate of drug delivery from these materials and, therefore, of the time window of action of the encapsulated therapeutic agents. Drug-release mechanisms uncovered! Coordination polymer nanoparticles loaded with coordinated and mechanically entrapped fluorescent guests were prepared as benchmark systems to investigate diffusion- and degradation-controlled drug delivery from these materials (see figure).
Ajuts: MINECO/MAT2012-38318-C03-02
MINECO/MAT2012-38319-C02-01
MINECO/CTQ2012-30853
MINECO/CTQ2010-15380
MINECO/JCI-2011-09239
Drets: Tots els drets reservats.
Llengua: Anglès
Document: article ; recerca ; Versió sotmesa a revisió
Matèria: Drug delivery ; Fluorescence ; Metal-organic frameworks ; Nanoparticles ; Polymers
Publicat a: Chemistry, Vol. 19, Issue 51 (December 2013) , p. 17508-17516, ISSN 1521-3765

DOI: 10.1002/chem.201302662


Preprint
13 p, 1.6 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > Grup d'Electroquímica, Fotoquímica i Reactivitat Orgànica (GEFRO)
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > Institut Català de Nanociència i Nanotecnologia (ICN2)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2019-06-12, darrera modificació el 2021-06-13



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