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Página principal > Artículos > Artículos publicados > A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine |
Fecha: | 2018 |
Resumen: | We present a low-cost integrated nanophotonic lab-on-a-chip platform suitable for point-of-care (POC) biomarker analysis. The sensor chip included in the platform contains multiplexed Mach-Zehnder interferometers with an on-chip optical spectral analyser consisting of an arrayed-waveguide grating. The sensor chip is fabricated in silicon nitride material, which makes it compatible with consumer-electronics-grade sources and detectors, leading to the possibility of low-cost instrumentation. The nanophotonic sensor chip exhibits a detection limit of 6 × 10 RIU (Refractive Index Units), which is in the same order of magnitude as the reported values for state-of-the-art evanescent wave sensors. The sensor chip is biofunctionalised with specific bioreceptors and integrated into a polymer microfluidic cartridge. The POC instrumentation platform contains optical excitation and read-out sub-systems and dedicated on-board software for real-time analysis of patient samples. To demonstrate the versatility of the platform, we present results both on the detection of an antigen related to tuberculosis directly in urine samples using a laboratory prototype and on the detection of a protein biomarker (CRP) related to inflammation using the integrated instrument. |
Nota: | Número d'acord de subvenció EC/FP7/610389 |
Nota: | Número d'acord de subvenció AGAUR/2014/SGR-624 |
Nota: | Número d'acord de subvenció MINECO/SEV-2013-0295 |
Derechos: | Tots els drets reservats. |
Lengua: | Anglès |
Documento: | article ; recerca ; submittedVersion ; acceptedVersion |
Materia: | Biosensing platforms ; Evanescent wave sensors ; Nitride materials ; On board softwares ; Polymer microfluidics ; Real time analysis ; Refractive index units ; State of the art |
Publicado en: | Analytical methods, Vol. 10, Issue 25 (July 2018) , p. 3066-3073, ISSN 1759-9679 |
Preprint 9 p, 1.1 MB |
Postprint 17 p, 991.7 KB |