Web of Science: 18 citations, Scopus: 20 citations, Google Scholar: citations
A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine
Martens, Daan (Ghent University)
Ramírez Priego, Patricia (Institut Català de Nanociència i Nanotecnologia)
Murib, M.S. (Ghent University)
Elamin, Ayssar A. (LIONEX Diagnostics and Therapeutics GmbH)
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia)
Stehr, M. (LIONEX Diagnostics and Therapeutics GmbH)
Jonas, F. (LIONEX Diagnostics and Therapeutics GmbH)
Anton, Birgit (Microfluidic ChipShop GmbH)
Hlawatsch, N. (Microfluidic ChipShop GmbH)
Soetaert, Pieterjan (Trinean NV)
Vos, Rita (Imec)
Stassen, A. (Imec)
Severi, S. (Imec)
Van Roy, Wim (Imec)
Bockstaele, Ronny (Trinean NV)
Becker, Holger (Microfluidic ChipShop GmbH)
Singh, M. (LIONEX Diagnostics and Therapeutics GmbH)
Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
Bienstman, Peter (Ghent University)

Date: 2018
Abstract: We present a low-cost integrated nanophotonic lab-on-a-chip platform suitable for point-of-care (POC) biomarker analysis. The sensor chip included in the platform contains multiplexed Mach-Zehnder interferometers with an on-chip optical spectral analyser consisting of an arrayed-waveguide grating. The sensor chip is fabricated in silicon nitride material, which makes it compatible with consumer-electronics-grade sources and detectors, leading to the possibility of low-cost instrumentation. The nanophotonic sensor chip exhibits a detection limit of 6 × 10 RIU (Refractive Index Units), which is in the same order of magnitude as the reported values for state-of-the-art evanescent wave sensors. The sensor chip is biofunctionalised with specific bioreceptors and integrated into a polymer microfluidic cartridge. The POC instrumentation platform contains optical excitation and read-out sub-systems and dedicated on-board software for real-time analysis of patient samples. To demonstrate the versatility of the platform, we present results both on the detection of an antigen related to tuberculosis directly in urine samples using a laboratory prototype and on the detection of a protein biomarker (CRP) related to inflammation using the integrated instrument.
Note: Número d'acord de subvenció EC/FP7/610389
Note: Número d'acord de subvenció AGAUR/2014/SGR-624
Note: Número d'acord de subvenció MINECO/SEV-2013-0295
Rights: Tots els drets reservats.
Language: Anglès
Document: article ; recerca ; submittedVersion ; acceptedVersion
Subject: Biosensing platforms ; Evanescent wave sensors ; Nitride materials ; On board softwares ; Polymer microfluidics ; Real time analysis ; Refractive index units ; State of the art
Published in: Analytical methods, Vol. 10, Issue 25 (July 2018) , p. 3066-3073, ISSN 1759-9679

DOI: 10.1039/c8ay00666k

9 p, 1.1 MB

17 p, 991.7 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2019-06-12, last modified 2021-03-01

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