Web of Science: 10 citations, Scopus: 8 citations, Google Scholar: citations,
Long-term effectiveness of irreversible electroporation in a murine model of colorectal liver metastasis
Sánchez-Velázquez, Patricia (Hospital del Mar (Barcelona, Catalunya))
Castellví, Quim (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions)
Villanueva Garatachea, Alberto (Institut Català d'Oncologia)
Iglesias, Mar (Hospital del Mar (Barcelona, Catalunya))
Quesada, Rita (Hospital del Mar (Barcelona, Catalunya))
Pañella, Clara (Hospital del Mar (Barcelona, Catalunya))
Cáceres, Marta (Hospital del Mar (Barcelona, Catalunya))
Dorcaratto, Dimitri (Hospital del Mar (Barcelona, Catalunya))
Andaluz Martínez, Anna (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Moll Sánchez, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Burdio, José Miguel (Universidad de Zaragoza. Departamento de Ingeniería Eléctrica)
Grande, L (Hospital del Mar (Barcelona, Catalunya))
Ivorra Cano, Antoni (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions)
Burdío, Fernando (Hospital del Mar (Barcelona, Catalunya))

Date: 2017
Abstract: Irreversible electroporation (IRE) has recently gained in popularity as an ablative technique, however little is known about its oncological long-term outcomes. To determine the long-time survival of animals treated with a high dose of IRE and which histological changes it induces in tumoral tissue, IRE ablation was performed in forty-six athymic-nude mice with KM12C tumors implanted in the liver by applying electric current with different voltages (2000V/cm, 1000V/cm). The tumors were allowed to continue to grow until the animals reached the end-point criteria. Histology was harvested and the extent of tumor necrosis was semi-quantitatively assessed. IRE treatment with the 2000V/cm protocol significantly prolonged median mouse survival from 74. 3±6. 9 days in the sham group to 112. 5±15. 2 days in the 2000V/cm group. No differences were observed between the mean survival of the 1000V/cm and the sham group (83. 2±16. 4 days, p=0. 62). Histology revealed 63. 05%±23. 12 of tumor necrosis in animals of the 2000V/cm group as compared to 17. 50%±2. 50 in the 1000V/cm group and 25. 6%±22. 1 in the Sham group (p=0. 001). IRE prolonged the survival of animals treated with the highest electric field (2000V/cm). The animals in this group showed significantly higher rate of tumoral necrosis.
Grants: Ministerio de Ciencia e Innovación TEC2014-52383-C3-R
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Published in: Scientific reports, Vol. 7 (2017) , art. 44821, ISSN 2045-2322

DOI: 10.1038/srep44821
PMID: 28327623


8 p, 1.6 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2019-06-18, last modified 2023-11-16



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